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Harnessing Peptides against lead pollution and poisoning: Achievements and prospects


Sauser, Luca; Shoshan, Michal S (2020). Harnessing Peptides against lead pollution and poisoning: Achievements and prospects. Journal of Inorganic Biochemistry, 212:111251.

Abstract

Among the broad applicability of peptides in numerous aspects of life and technologies, their interactions with lead (Pb), one of the most harmful substances to the environment and health, are constantly explored. So far, peptides were developed for environmental remediation of Pb-contaminations by various strategies such as hydrogelation and surface display. They were also designed for Pb detection and sensing by electrochemical and fluorescent methods and for modeling natural proteins that involve in mechanisms by which Pb is toxic. This review aims at summarizing selected examples of these applications, manifesting the enormous potential of peptides in the combat against Pb pollution. Nevertheless, the absence of new medicinal treatments against Pb poisoning that are based on peptides is noticeable. An overview of previous achievements utilizing Pb-peptide interactions towards various goals is presented and can be therefore leveraged to construct a useful toolbox for the design of smart peptides as next-generation therapeutics against Pb.

Abstract

Among the broad applicability of peptides in numerous aspects of life and technologies, their interactions with lead (Pb), one of the most harmful substances to the environment and health, are constantly explored. So far, peptides were developed for environmental remediation of Pb-contaminations by various strategies such as hydrogelation and surface display. They were also designed for Pb detection and sensing by electrochemical and fluorescent methods and for modeling natural proteins that involve in mechanisms by which Pb is toxic. This review aims at summarizing selected examples of these applications, manifesting the enormous potential of peptides in the combat against Pb pollution. Nevertheless, the absence of new medicinal treatments against Pb poisoning that are based on peptides is noticeable. An overview of previous achievements utilizing Pb-peptide interactions towards various goals is presented and can be therefore leveraged to construct a useful toolbox for the design of smart peptides as next-generation therapeutics against Pb.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Life Sciences > Biochemistry
Physical Sciences > Inorganic Chemistry
Uncontrolled Keywords:Inorganic Chemistry, Biochemistry
Language:English
Date:1 November 2020
Deposited On:03 Feb 2021 16:07
Last Modified:04 Feb 2021 21:01
Publisher:Elsevier
ISSN:0162-0134
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.jinorgbio.2020.111251
PubMed ID:32920433
Project Information:
  • : FunderSNSF
  • : Grant IDPZ00P2_179818
  • : Project TitleSelective Heavy Metal Detoxification by Short Peptides: A New Approach for Chelation Therapy
  • : FunderUZH
  • : Grant IDK-73521-11-01
  • : Project TitleForschungskredit

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Embargo till: 2022-11-01