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Autophagy Pathways in CNS Myeloid Cell Immune Functions


Keller, Christian W; Münz, Christian; Lünemann, Jan D (2020). Autophagy Pathways in CNS Myeloid Cell Immune Functions. Trends in Neurosciences, 43(12):1024-1033.

Abstract

The CNS accommodates a diverse myeloid immune cell compartment that maintains CNS homeostasis in the steady state while contributing to tissue injury during infectious, autoimmune, and neurodegenerative disease conditions. Autophagy and autophagy proteins play fundamental roles in myeloid cell-related immune functions. Many of these processes do not necessarily involve the canonical formation of a double-membrane structure known as the 'autophagosome' and reflect noncanonical functions of the autophagy machinery. Here, we illustrate recent insights, concepts, and outstanding questions regarding how autophagy pathways in myeloid cells contribute to brain health and disease.

Abstract

The CNS accommodates a diverse myeloid immune cell compartment that maintains CNS homeostasis in the steady state while contributing to tissue injury during infectious, autoimmune, and neurodegenerative disease conditions. Autophagy and autophagy proteins play fundamental roles in myeloid cell-related immune functions. Many of these processes do not necessarily involve the canonical formation of a double-membrane structure known as the 'autophagosome' and reflect noncanonical functions of the autophagy machinery. Here, we illustrate recent insights, concepts, and outstanding questions regarding how autophagy pathways in myeloid cells contribute to brain health and disease.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Uncontrolled Keywords:General Neuroscience
Language:English
Date:1 December 2020
Deposited On:04 Feb 2021 14:41
Last Modified:05 Feb 2021 21:05
Publisher:Elsevier
ISSN:0166-2236
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.tins.2020.09.003
PubMed ID:33010946
Project Information:
  • : FunderSNSF
  • : Grant ID31003A_169664
  • : Project TitleNOX2-regulated Antigen Presentation in CNS Autoimmunity
  • : FunderSNSF
  • : Grant ID310030B_182827
  • : Project TitleExcellence Grant - Role of autophagy proteins in endocytosis and exocytosis
  • : FunderSNSF
  • : Grant IDCRSII5_180323
  • : Project TitleNovel virucidal drugs: From basic to in vivo studies

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Embargo till: 2021-09-30