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Cytotoxicity in Epstein Barr virus specific immune control


Münz, Christian (2021). Cytotoxicity in Epstein Barr virus specific immune control. Current Opinion in Virology, 46:1-8.

Abstract

Epstein Barr virus (EBV) is the most common human tumor virus, persistently infecting more than 95% of the human adult population and readily transforming human B cell in culture. Fortunately, only a small minority of EBV carriers develops virus associated malignancies. The majority controls persistent EBV infection with cytotoxic lymphocytes, mainly NK, γδ and CD8+ T cells and the characteristics of the required immune responses get more and more defined by primary immunodeficiencies that affect molecules of these cytotoxic lymphocytes and their investigation in mice with reconstituted human immune system components (humanized mice) that are susceptible to EBV infection and associated lymphomagenesis. The gained information should be able to guide us to develop immunotherapies against EBV and tumors in general.

Abstract

Epstein Barr virus (EBV) is the most common human tumor virus, persistently infecting more than 95% of the human adult population and readily transforming human B cell in culture. Fortunately, only a small minority of EBV carriers develops virus associated malignancies. The majority controls persistent EBV infection with cytotoxic lymphocytes, mainly NK, γδ and CD8+ T cells and the characteristics of the required immune responses get more and more defined by primary immunodeficiencies that affect molecules of these cytotoxic lymphocytes and their investigation in mice with reconstituted human immune system components (humanized mice) that are susceptible to EBV infection and associated lymphomagenesis. The gained information should be able to guide us to develop immunotherapies against EBV and tumors in general.

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Additional indexing

Item Type:Journal Article, not_refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > Virology
Uncontrolled Keywords:Virology
Language:English
Date:1 February 2021
Deposited On:04 Feb 2021 13:53
Last Modified:05 Feb 2021 21:05
Publisher:Elsevier
ISSN:1879-6257
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.coviro.2020.07.011
PubMed ID:32771660
Project Information:
  • : FunderSNSF
  • : Grant ID310030B_182827
  • : Project TitleExcellence Grant - Role of autophagy proteins in endocytosis and exocytosis
  • : FunderSNSF
  • : Grant IDCRSII5_180323
  • : Project TitleNovel virucidal drugs: From basic to in vivo studies

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Embargo till: 2022-02-01