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High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential


Jomard, Anne; Osto, Elena (2020). High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential. Frontiers in cardiovascular medicine, 7:39.

Abstract

High Density Lipoproteins (HDLs) have long been considered as "good cholesterol," beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes.

Abstract

High Density Lipoproteins (HDLs) have long been considered as "good cholesterol," beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are complex particles that undergoes dynamic remodeling through interactions with various enzymes and tissues throughout their life cycle, making the complete understanding of its functions and roles more complicated than initially expected. In this review, we explore the novel understanding of HDLs' behavior in health and disease as a multifaceted class of lipoprotein, with different size subclasses, molecular composition, receptor interactions, and functionality. Further, we report on emergent HDL-based therapeutics tested in small and larger scale clinical trials and their mixed successes.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:31 March 2020
Deposited On:05 Feb 2021 11:56
Last Modified:10 Feb 2021 07:03
Publisher:Frontiers Research Foundation
ISSN:2297-055X
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fcvm.2020.00039
PubMed ID:32296714

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