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Design, Synthesis, and Biological Evaluation of Next Generation Fidaxomicin Antibiotics


Dorst, Andrea. Design, Synthesis, and Biological Evaluation of Next Generation Fidaxomicin Antibiotics. 2020, University of Zurich, Faculty of Science.

Abstract

Natural products and natural product derived compounds are popular sources of new drugs and thus also play a pivotal role in the discovery and development of new antibiotics. The antibiotic fidaxomicin possesses promising antibacterial activity against several Gram-positive bacteria, though the poor bioavailability due to low water solubility, highly limits its clinical application. This thesis deals with our efforts to semisynthetically modify the macrocyclic antibiotic fidaxomicin (1) and presents our approaches starting from the isolation of this complex natural product from its natural source, the actinobacteria Actinoplanes deccanensis.

Abstract

Natural products and natural product derived compounds are popular sources of new drugs and thus also play a pivotal role in the discovery and development of new antibiotics. The antibiotic fidaxomicin possesses promising antibacterial activity against several Gram-positive bacteria, though the poor bioavailability due to low water solubility, highly limits its clinical application. This thesis deals with our efforts to semisynthetically modify the macrocyclic antibiotic fidaxomicin (1) and presents our approaches starting from the isolation of this complex natural product from its natural source, the actinobacteria Actinoplanes deccanensis.

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Additional indexing

Item Type:Dissertation (monographical)
Referees:Gademann Karl, Juricek Michal, Sigel Roland K O
Communities & Collections:07 Faculty of Science > Department of Chemistry
UZH Dissertations
Dewey Decimal Classification:540 Chemistry
Language:English
Place of Publication:Zürich
Date:2020
Deposited On:12 Feb 2021 07:40
Last Modified:13 Feb 2021 04:40
OA Status:Closed

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Embargo till: 2023-12-01