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Membrane lipids and transporter function


Stieger, Bruno; Steiger, Julia; Locher, Kaspar P (2021). Membrane lipids and transporter function. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1867(5):166079.

Abstract

Transport proteins are essential for cells in allowing the exchange of substances between cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids modulate the function of transmembrane proteins such as transporters in two ways: Lipids are tightly and specifically bound to transport proteins and in addition they modulate from the bulk of the lipid bilayer the function of transport proteins. This overview summarizes currently available information at the ultrastructural level on lipids tightly bound to transport proteins and the impact of altered bulk membrane lipid composition. Human diseases leading to altered lipid homeostasis will lead to altered membrane lipid composition, which in turn affect the function of transporter proteins.

Abstract

Transport proteins are essential for cells in allowing the exchange of substances between cells and their environment across the lipid bilayer forming a tight barrier. Membrane lipids modulate the function of transmembrane proteins such as transporters in two ways: Lipids are tightly and specifically bound to transport proteins and in addition they modulate from the bulk of the lipid bilayer the function of transport proteins. This overview summarizes currently available information at the ultrastructural level on lipids tightly bound to transport proteins and the impact of altered bulk membrane lipid composition. Human diseases leading to altered lipid homeostasis will lead to altered membrane lipid composition, which in turn affect the function of transporter proteins.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Medicine
Life Sciences > Molecular Biology
Uncontrolled Keywords:Molecular Medicine, Molecular Biology
Language:English
Date:1 May 2021
Deposited On:12 Feb 2021 12:09
Last Modified:13 Feb 2021 21:00
Publisher:Elsevier
ISSN:0925-4439
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.bbadis.2021.166079
PubMed ID:33476785
Project Information:
  • : FunderSNSF
  • : Grant ID310030_166563
  • : Project TitleRole of Membrane Lipid Environment on the Transport Acitivity of Hepatocellular Organic Anion Transporters
  • : FunderSNSF
  • : Grant ID310030_189111
  • : Project TitleStructural and mechanistic studies of liver ABC transporters

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