Header

UZH-Logo

Maintenance Infos

An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease


Pei, Ke; Gui, Ting; Kan, Dongfang; Feng, Huichao; Jin, Yanqiang; Yang, Ying; Zhang, Qian; Du, Ziwei; Gai, Zhibo; Wu, Jibiao; Li, Yunlun (2020). An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease. BioMed Research International, 2020:4020249.

Abstract

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.

Abstract

The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.

Statistics

Citations

Altmetrics

Downloads

2 downloads since deposited on 12 Feb 2021
2 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Life Sciences > General Immunology and Microbiology
Uncontrolled Keywords:General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Medicine
Language:English
Date:18 July 2020
Deposited On:12 Feb 2021 15:24
Last Modified:13 Feb 2021 21:00
Publisher:Hindawi Publishing Corporation
ISSN:2314-6133
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1155/2020/4020249
PubMed ID:32733940

Download

Gold Open Access

Download PDF  'An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 672kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)