Header

UZH-Logo

Maintenance Infos

Mycobacterium avium: an emerging pathogen for dog breeds with hereditary immunodeficiencies


Ghielmetti, Giovanni; Giger, Urs (2020). Mycobacterium avium: an emerging pathogen for dog breeds with hereditary immunodeficiencies. Current Clinical Microbiology Reports, 7(3):67-80.

Abstract

Purpose of Review: Among the non-tuberculous mycobacteria (NTM), Mycobacterium avium complex (MAC) is the leading cause of pulmonary disease in humans. Innate and acquired immunodeficiencies have been associated with an increased host susceptibility to NTM infections. The underlying mechanisms predisposing humans and dogs to MAC infections are being elucidated.
Recent Findings: Although MAC infection is infrequently diagnosed in dogs, a strong breed predisposition particularly for Miniature Schnauzer and Basset Hound dogs is evident. A recessively inherited defect of the adaptor protein CARD9 has recently been documented to be responsible for the increased susceptibility to MAC in the Miniature Schnauzer breed.
Summary: Given the zoonotic potential of a MAC-infected dog particularly to immunocompromised human patients, diseased dogs pose a public health risk. While not a reportable disease, treatment of systemic mycobacteriosis is generally not effective and discouraged in dogs. The collaborative efforts by microbiologists, veterinary clinicians, dog breeders, primary care physicians, and infectious disease specialists applying the One Health approach are therefore crucial for the best management and prevention of MAC infection

Abstract

Purpose of Review: Among the non-tuberculous mycobacteria (NTM), Mycobacterium avium complex (MAC) is the leading cause of pulmonary disease in humans. Innate and acquired immunodeficiencies have been associated with an increased host susceptibility to NTM infections. The underlying mechanisms predisposing humans and dogs to MAC infections are being elucidated.
Recent Findings: Although MAC infection is infrequently diagnosed in dogs, a strong breed predisposition particularly for Miniature Schnauzer and Basset Hound dogs is evident. A recessively inherited defect of the adaptor protein CARD9 has recently been documented to be responsible for the increased susceptibility to MAC in the Miniature Schnauzer breed.
Summary: Given the zoonotic potential of a MAC-infected dog particularly to immunocompromised human patients, diseased dogs pose a public health risk. While not a reportable disease, treatment of systemic mycobacteriosis is generally not effective and discouraged in dogs. The collaborative efforts by microbiologists, veterinary clinicians, dog breeders, primary care physicians, and infectious disease specialists applying the One Health approach are therefore crucial for the best management and prevention of MAC infection

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Downloads

2 downloads since deposited on 16 Feb 2021
2 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Food Safety and Hygiene
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Microbiology (medical)
Health Sciences > Infectious Diseases
Language:English
Date:1 September 2020
Deposited On:16 Feb 2021 17:00
Last Modified:18 Feb 2021 11:43
Publisher:Springer
ISSN:2196-5471
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1007/s40588-020-00145-5

Download

Hybrid Open Access

Download PDF  'Mycobacterium avium: an emerging pathogen for dog breeds with hereditary immunodeficiencies'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 808kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)