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Coming out of the PiTs-novel strategies for controlling intestinal phosphate absorption in patients with CKD


Wagner, Carsten A (2020). Coming out of the PiTs-novel strategies for controlling intestinal phosphate absorption in patients with CKD. Kidney International, 98(2):273-275.

Abstract

The kidneys are the gatekeepers of phosphate balance, and loss of kidney function causes a profound disturbance of mineral metabolism. Patients with chronic kidney disease suffer from an excessive cardiovascular disease risk with a high morbidity and mortality. Current therapies aimed at reducing total phosphate body load are insufficient, and novel strategies are urgently needed. In this issue, Tsuboi and colleagues provide evidence for the use of a novel phosphate transporter inhibitor to reduce intestinal phosphate absorption.

Abstract

The kidneys are the gatekeepers of phosphate balance, and loss of kidney function causes a profound disturbance of mineral metabolism. Patients with chronic kidney disease suffer from an excessive cardiovascular disease risk with a high morbidity and mortality. Current therapies aimed at reducing total phosphate body load are insufficient, and novel strategies are urgently needed. In this issue, Tsuboi and colleagues provide evidence for the use of a novel phosphate transporter inhibitor to reduce intestinal phosphate absorption.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Nephrology
Language:English
Date:August 2020
Deposited On:16 Feb 2021 12:05
Last Modified:14 Feb 2022 16:04
Publisher:Elsevier
ISSN:0085-2538
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.kint.2020.04.010
PubMed ID:32709284

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