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Estimation of planning organ at risk volumes for ocular structures in dogs undergoing three‐dimensional image‐guided periocular radiotherapy with rigid bite block immobilization

Wolf, Friederike; Rohrer Bley, Carla; Besserer, Jürgen; Meier, Valeria Sabina (2021). Estimation of planning organ at risk volumes for ocular structures in dogs undergoing three‐dimensional image‐guided periocular radiotherapy with rigid bite block immobilization. Veterinary Radiology & Ultrasound, 62(2):246-254.

Abstract

Planning organ at risk volume (PRV) estimates have been reported as methods for sparing organs at risk (OARs) during radiation therapy, especially for hypofractioned and/or dose-escalated protocols. The objectives of this retrospective, analytical, observational study were to evaluate peri-ocular OAR shifts and derive PRVs in a sample of dogs undergoing radiation therapy for periocular tumors. Inclusion criteria were as follows: dogs irradiated for periocular tumors, with 3D-image-guidance and at least four cone-beam CTs (CBCTs) used for position verification, and positioning in a rigid bite block immobilization device. Peri-ocular OARs were contoured on each CBCT and the systematic and random error of the shifts in relation to the planning CT position computed. The formula 1.3×Σ+0.5xσ was used to generate a PRV of each OAR in the dorsoventral, mediolateral, and craniocaudal axis. A total of 30 dogs were sampled, with 450 OARs contoured, and 2145 shifts assessed. The PRV expansion was qualitatively different for each organ (1-4 mm for the dorsoventral and 1-2 mm for the mediolateral and craniocaudal axes). Maximal PRV expansion was ≤4 mm and directional for the majority; most pronounced for corneas and retinas. Findings from the current study may help improve awareness of and minimization of radiation dose in peri-ocular OARs for future canine patients. Because some OARs were difficult to visualize on CBCTs and/ or to delineate on the planning CT, authors recommend that PRV estimates be institution-specific and applied with caution.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Physics Institute
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Health Sciences > General Veterinary
Uncontrolled Keywords:General Veterinary
Language:English
Date:1 March 2021
Deposited On:16 Feb 2021 17:44
Last Modified:25 Aug 2024 01:38
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1058-8183
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/vru.12955
PubMed ID:33460237
Project Information:
  • Funder: SNSF
  • Grant ID: 320030_182490
  • Project Title: Challenging traditional radiation dose homogeneity: using normal tissue tolerance for heterogeneous dose escalation and better tumor control
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  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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