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A 'Marginal' tale: the development of the neocortical layer 1


Gesuita, Lorenzo; Karayannis, Theofanis (2020). A 'Marginal' tale: the development of the neocortical layer 1. Current Opinion in Neurobiology, 66:37-47.

Abstract

The development of neocortical layer 1 is a very dynamic process and the scene of multiple transient events, with Cajal-Retzius cell death being one of the most characteristic ones. Layer 1 is also the route of migration for a substantial number of GABAergic interneurons during embryogenesis and where some of which will ultimately remain in the adult. The two cell types, together with a diverse set of incoming axons and dendrites, create an early circuit that will dramatically change in structure and function in the adult cortex to give prominence to inhibition. Through the engagement of a diverse set of GABAergic inhibitory cells by bottom-up and top-down inputs, adult layer 1 becomes a powerful computational platform for the neocortex.

Abstract

The development of neocortical layer 1 is a very dynamic process and the scene of multiple transient events, with Cajal-Retzius cell death being one of the most characteristic ones. Layer 1 is also the route of migration for a substantial number of GABAergic interneurons during embryogenesis and where some of which will ultimately remain in the adult. The two cell types, together with a diverse set of incoming axons and dendrites, create an early circuit that will dramatically change in structure and function in the adult cortex to give prominence to inhibition. Through the engagement of a diverse set of GABAergic inhibitory cells by bottom-up and top-down inputs, adult layer 1 becomes a powerful computational platform for the neocortex.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:15 October 2020
Deposited On:17 Feb 2021 07:22
Last Modified:18 Feb 2021 21:00
Publisher:Elsevier
ISSN:0959-4388
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.conb.2020.09.002
PubMed ID:33069991

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