Header

UZH-Logo

Maintenance Infos

Acquisition and carriage of multidrug‐resistant organisms in dogs and cats presented to small animal practices and clinics in Switzerland


Dazio, Valentina; Nigg, Aurélien; Schmidt, Janne S; Brilhante, Michael; Mauri, Nico; Kuster, Stephan P; Brawand, Stefanie Gobeli; Schüpbach‐Regula, Gertraud; Willi, Barbara; Endimiani, Andrea; Perreten, Vincent; Schuller, Simone (2021). Acquisition and carriage of multidrug‐resistant organisms in dogs and cats presented to small animal practices and clinics in Switzerland. Journal of Veterinary Internal Medicine:Epub ahead of print.

Abstract

Background: The emergence and spread of multidrug-resistant organisms (MDRO) present a threat to human and animal health.
Objectives: To assess acquisition, prevalence of and risk factors for MDRO carriage in dogs and cats presented to veterinary clinics or practices in Switzerland.
Animals: Privately owned dogs (n = 183) and cats (n = 88) presented to 4 veterinary hospitals and 1 practice.
Methods: Prospective, longitudinal, observational study. Oronasal and rectal swabs were collected at presentation and 69% of animals were sampled again at discharge. Methicillin-resistant (MR) staphylococci and macrococci, cephalosporinase-, and carbapenemase-producing (CP) Enterobacterales were isolated. Genetic relatedness of isolates was assessed by repetitive sequence-based polymerase chain reaction and multilocus sequence typing. Risk factors for MDRO acquisition and carriage were analyzed based on questionnaire-derived and hospitalization data.
Results: Admission prevalence of MDRO carriage in pets was 15.5% (95% confidence interval [CI], 11.4-20.4). The discharge prevalence and acquisition rates were 32.1% (95% CI, 25.5-39.3) and 28.3% (95% CI, 22-35.4), respectively. Predominant hospital-acquired isolates were extended spectrum β-lactamase-producing Escherichia coli (ESBL-E coli; 17.3%) and β-lactamase-producing Klebsiella pneumoniae (13.7%). At 1 institution, a cluster of 24 highly genetically related CP (blaoxa181 and blaoxa48 ) was identified. Multivariate analysis identified hospitalization at clinic 1 (odds ratio [OR], 5.1; 95% CI, 1.6-16.8) and days of hospitalization (OR 3-5 days, 4.4; 95% CI, 1.8-10.9; OR > 5 days, 6.2; 95% CI, 1.3-28.8) as risk factors for MDRO acquisition in dogs.
Conclusions: Veterinary hospitals play an important role in the selection and transmission of MDRO among veterinary patients.

Abstract

Background: The emergence and spread of multidrug-resistant organisms (MDRO) present a threat to human and animal health.
Objectives: To assess acquisition, prevalence of and risk factors for MDRO carriage in dogs and cats presented to veterinary clinics or practices in Switzerland.
Animals: Privately owned dogs (n = 183) and cats (n = 88) presented to 4 veterinary hospitals and 1 practice.
Methods: Prospective, longitudinal, observational study. Oronasal and rectal swabs were collected at presentation and 69% of animals were sampled again at discharge. Methicillin-resistant (MR) staphylococci and macrococci, cephalosporinase-, and carbapenemase-producing (CP) Enterobacterales were isolated. Genetic relatedness of isolates was assessed by repetitive sequence-based polymerase chain reaction and multilocus sequence typing. Risk factors for MDRO acquisition and carriage were analyzed based on questionnaire-derived and hospitalization data.
Results: Admission prevalence of MDRO carriage in pets was 15.5% (95% confidence interval [CI], 11.4-20.4). The discharge prevalence and acquisition rates were 32.1% (95% CI, 25.5-39.3) and 28.3% (95% CI, 22-35.4), respectively. Predominant hospital-acquired isolates were extended spectrum β-lactamase-producing Escherichia coli (ESBL-E coli; 17.3%) and β-lactamase-producing Klebsiella pneumoniae (13.7%). At 1 institution, a cluster of 24 highly genetically related CP (blaoxa181 and blaoxa48 ) was identified. Multivariate analysis identified hospitalization at clinic 1 (odds ratio [OR], 5.1; 95% CI, 1.6-16.8) and days of hospitalization (OR 3-5 days, 4.4; 95% CI, 1.8-10.9; OR > 5 days, 6.2; 95% CI, 1.3-28.8) as risk factors for MDRO acquisition in dogs.
Conclusions: Veterinary hospitals play an important role in the selection and transmission of MDRO among veterinary patients.

Statistics

Citations

Altmetrics

Downloads

3 downloads since deposited on 17 Feb 2021
3 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Scopus Subject Areas:Health Sciences > General Veterinary
Uncontrolled Keywords:General Veterinary
Language:English
Date:1 February 2021
Deposited On:17 Feb 2021 15:53
Last Modified:18 Feb 2021 21:00
Publisher:Wiley Open Access
ISSN:0891-6640
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jvim.16038

Download

Gold Open Access

Download PDF  'Acquisition and carriage of multidrug‐resistant organisms in dogs and cats presented to small animal practices and clinics in Switzerland'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 673kB
View at publisher
Licence: Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)