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Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease


Haider, Ahmed; Bengs, Susan; Diggelmann, Flavia; Epprecht, Gioia; Etter, Dominik; Beeler, Anna Luisa; Wijnen, Winandus J; Treyer, Valerie; Portmann, Angela; Warnock, Geoffrey I; Grämer, Muriel; Todorov, Atanas; Fuchs, Tobias A; Pazhenkottil, Aju P; Buechel, Ronny R; Tanner, Felix C; Kaufmann, Philipp A; Gebhard, Catherine; Fiechter, Michael (2021). Age- and sex-dependent changes of resting amygdalar activity in individuals free of clinical cardiovascular disease. Journal of Nuclear Cardiology:Epub ahead of print.

Abstract

Purpose: Amygdalar metabolic activity was shown to independently predict cardiovascular outcomes. However, little is known about age- and sex-dependent variability in neuronal stress responses among individuals free of cardiac disease. This study sought to assess age- and sex-specific differences of resting amygdalar metabolic activity in the absence of clinical cardiovascular disease.

Methods: Amygdalar metabolic activity was assessed in 563 patients who underwent multimodality imaging by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography and echocardiography for the evaluation of cardiac function.

Results: After exclusion of 294 patients with structural or functional cardiovascular pathologies, 269 patients (128 women) remained in the final population. 18F-FDG amygdalar activity significantly decreased with age in men (r = - 0.278, P = 0.001), but not in women (r = 0.002, P = 0.983). Similarly, dichotomous analysis confirmed a lower amygdalar activity in men ≥ 50 years as compared to those < 50 years of age (0.79 ± 0.1 vs. 0.84 ± 0.1, P = 0.007), which was not observed in women (0.81 ± 0.1 vs. 0.82 ± 0.1, P = 0.549). Accordingly, a fully adjusted linear regression analysis identified age as an independent predictor of amygdalar activity only in men (B-coefficient - 0.278, P = 0.001).

Conclusion: Amygdalar activity decreases with age in men, but not in women. The use of amygdalar activity for cardiovascular risk stratification merits consideration of inherent age- and sex-dependent variability.

Keywords: 18F-fluorodeoxyglucose (18F-FDG); Amygdala; aging; cardiovascular disease; echocardiography; emotional stress; heart-brain axis; positron emission tomography (PET); risk stratification; sex differences.

Abstract

Purpose: Amygdalar metabolic activity was shown to independently predict cardiovascular outcomes. However, little is known about age- and sex-dependent variability in neuronal stress responses among individuals free of cardiac disease. This study sought to assess age- and sex-specific differences of resting amygdalar metabolic activity in the absence of clinical cardiovascular disease.

Methods: Amygdalar metabolic activity was assessed in 563 patients who underwent multimodality imaging by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography and echocardiography for the evaluation of cardiac function.

Results: After exclusion of 294 patients with structural or functional cardiovascular pathologies, 269 patients (128 women) remained in the final population. 18F-FDG amygdalar activity significantly decreased with age in men (r = - 0.278, P = 0.001), but not in women (r = 0.002, P = 0.983). Similarly, dichotomous analysis confirmed a lower amygdalar activity in men ≥ 50 years as compared to those < 50 years of age (0.79 ± 0.1 vs. 0.84 ± 0.1, P = 0.007), which was not observed in women (0.81 ± 0.1 vs. 0.82 ± 0.1, P = 0.549). Accordingly, a fully adjusted linear regression analysis identified age as an independent predictor of amygdalar activity only in men (B-coefficient - 0.278, P = 0.001).

Conclusion: Amygdalar activity decreases with age in men, but not in women. The use of amygdalar activity for cardiovascular risk stratification merits consideration of inherent age- and sex-dependent variability.

Keywords: 18F-fluorodeoxyglucose (18F-FDG); Amygdala; aging; cardiovascular disease; echocardiography; emotional stress; heart-brain axis; positron emission tomography (PET); risk stratification; sex differences.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Radiology, Nuclear Medicine and Imaging
Health Sciences > Cardiology and Cardiovascular Medicine
Language:English
Date:13 January 2021
Deposited On:22 Feb 2021 14:30
Last Modified:23 Feb 2021 21:01
Publisher:Springer
ISSN:1071-3581
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s12350-020-02504-7
PubMed ID:33442821

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