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The Hammer and the Dance of Cell Cycle Control


Panagopoulos, Andreas; Altmeyer, Matthias (2020). The Hammer and the Dance of Cell Cycle Control. Trends in Biochemical Sciences, 46(4):301-314.

Abstract

Cell cycle checkpoints secure ordered progression from one cell cycle phaseto the next. They are important to signal cell stress and DNA lesions and tostop cell cycle progression when severe problems occur. Recent work suggests,however, that the cell cycle control machinery responds in more subtle andsophisticated ways when cells are faced with naturally occurring challenges,such as replication impediments associated with endogenous replication stress.Instead of following a stop and go approach, cells usefine-tuned decelerationand brake release mechanisms under the control of ataxia telangiectasia andRad3-related protein kinase (ATR) and checkpoint kinase 1 (CHK1) to moreflex-ibly adapt their cell cycle program to changing conditions. We highlight emergingexamples of such intrinsic cell cycle checkpoint regulation and discuss theirphysiological and clinical relevance.

Abstract

Cell cycle checkpoints secure ordered progression from one cell cycle phaseto the next. They are important to signal cell stress and DNA lesions and tostop cell cycle progression when severe problems occur. Recent work suggests,however, that the cell cycle control machinery responds in more subtle andsophisticated ways when cells are faced with naturally occurring challenges,such as replication impediments associated with endogenous replication stress.Instead of following a stop and go approach, cells usefine-tuned decelerationand brake release mechanisms under the control of ataxia telangiectasia andRad3-related protein kinase (ATR) and checkpoint kinase 1 (CHK1) to moreflex-ibly adapt their cell cycle program to changing conditions. We highlight emergingexamples of such intrinsic cell cycle checkpoint regulation and discuss theirphysiological and clinical relevance.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Department of Molecular Mechanisms of Disease
07 Faculty of Science > Department of Molecular Mechanisms of Disease
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Biochemistry
Life Sciences > Molecular Biology
Language:English
Date:2020
Deposited On:16 Mar 2021 17:45
Last Modified:25 Jun 2024 01:38
Publisher:Elsevier
ISSN:0968-0004
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.tibs.2020.11.002
PubMed ID:33279370
  • Content: Published Version
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)