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Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020


Abstract

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

Abstract

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3–23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Epidemiology
Health Sciences > Public Health, Environmental and Occupational Health
Life Sciences > Virology
Language:English
Date:19 March 2020
Deposited On:31 Mar 2021 07:51
Last Modified:05 Jun 2022 07:22
Publisher:Centre Europeen pour la Surveillance Epidemiologique du SIDA
ISSN:1025-496X
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.2807/1560-7917.es.2020.25.11.2000266
PubMed ID:32209163
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)