# Multiple b-values improve discrimination of cortical gray matter regions using diffusion MRI: an experimental validation with a data-driven approach

Ganepola, Tara; Lee, Yoojin; Alexander, Daniel C; Sereno, Martin I; Nagy, Zoltan (2021). Multiple b-values improve discrimination of cortical gray matter regions using diffusion MRI: an experimental validation with a data-driven approach. Magma, 34(5):677-687.

## Abstract

Objective
To investigate whether varied or repeated b-values provide better diffusion MRI data for discriminating cortical areas with a data-driven approach.
Methods
Data were acquired from three volunteers at 1.5T with b-values of 800, 1400, 2000 s/mm$^{2}$ along 64 diffusion-encoding directions. The diffusion signal was sampled from gray matter in seven regions of interest (ROIs). Rotational invariants of the local diffusion profile were extracted as features that characterize local tissue properties. Random forest classification experiments assessed whether classification accuracy improved when data with multiple b-values were used over repeated acquisition of the same (1400 s/mm$^{2}$) b-value to compare all possible pairs of the seven ROIs. Three data sets from the Human Connectome Project were subjected to similar processing and analysis pipelines in eight ROIs.
Results
Three different b-values showed an average improvement in correct classification rates of 5.6% and 4.6%, respectively, in the local and HCP data over repeated measurements of the same b-value. The improvement in correct classification rate reached as high as 16% for individual binary classification experiments between two ROIs. Often using only two of the available three b-values were adequate to make such an improvement in classification rates.
Conclusion
Acquisitions with varying b-values are more suitable for discriminating cortical areas.

## Abstract

Objective
To investigate whether varied or repeated b-values provide better diffusion MRI data for discriminating cortical areas with a data-driven approach.
Methods
Data were acquired from three volunteers at 1.5T with b-values of 800, 1400, 2000 s/mm$^{2}$ along 64 diffusion-encoding directions. The diffusion signal was sampled from gray matter in seven regions of interest (ROIs). Rotational invariants of the local diffusion profile were extracted as features that characterize local tissue properties. Random forest classification experiments assessed whether classification accuracy improved when data with multiple b-values were used over repeated acquisition of the same (1400 s/mm$^{2}$) b-value to compare all possible pairs of the seven ROIs. Three data sets from the Human Connectome Project were subjected to similar processing and analysis pipelines in eight ROIs.
Results
Three different b-values showed an average improvement in correct classification rates of 5.6% and 4.6%, respectively, in the local and HCP data over repeated measurements of the same b-value. The improvement in correct classification rate reached as high as 16% for individual binary classification experiments between two ROIs. Often using only two of the available three b-values were adequate to make such an improvement in classification rates.
Conclusion
Acquisitions with varying b-values are more suitable for discriminating cortical areas.

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