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Real-world stress resilience is associated with the responsivity of the locus coeruleus

Grueschow, Marcus; Stenz, Nico; Thörn, Hanna; Ehlert, Ulrike; Breckwoldt, Jan; Brodmann Maeder, Monika; Exadaktylos, Aristomenis K; Bingisser, Roland; Ruff, Christian C; Kleim, Birgit (2021). Real-world stress resilience is associated with the responsivity of the locus coeruleus. Nature Communications, 12(1):2275.

Abstract

Individuals may show different responses to stressful events. Here, we investigate the neurobiological basis of stress resilience, by showing that neural responsitivity of the noradrenergic locus coeruleus (LC-NE) and associated pupil responses are related to the subsequent change in measures of anxiety and depression in response to prolonged real-life stress. We acquired fMRI and pupillometry data during an emotional-conflict task in medical residents before they underwent stressful emergency-room internships known to be a risk factor for anxiety and depression. The LC-NE conflict response and its functional coupling with the amygdala was associated with stress-related symptom changes in response to the internship. A similar relationship was found for pupil-dilation, a potential marker of LC-NE firing. Our results provide insights into the noradrenergic basis of conflict generation, adaptation and stress resilience.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
06 Faculty of Arts > Institute of Psychology
04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
Dewey Decimal Classification:150 Psychology
Scopus Subject Areas:Physical Sciences > General Chemistry
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Physical Sciences > General Physics and Astronomy
Scope:Discipline-based scholarship (basic research)
Language:English
Date:15 April 2021
Deposited On:18 May 2021 11:48
Last Modified:25 Oct 2024 01:39
Publisher:Nature Publishing Group
ISSN:2041-1723
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/s41467-021-22509-1
PubMed ID:33859187
Other Identification Number:merlin-id:21070
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  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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