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On the reproducibility of in vivo temporal signal-to-noise ratio and its utility as a predictor of subject-level t-values in a functional magnetic resonance imaging study


Gobbi, Susanna; Lee, Yoojin; Homolya, István; Tobler, Philippe N; Hare, Todd A; Nagy, Zoltan (2021). On the reproducibility of in vivo temporal signal-to-noise ratio and its utility as a predictor of subject-level t-values in a functional magnetic resonance imaging study. International Journal of Imaging Systems and Technology, 31(4):1849-1860.

Abstract

The aim of this study was to evaluate the reproducibility of voxel-wise temporal signal-to-noise ratio (tSNR) on repeated scans across runs, sessions, and days. A group of 21 participants was scanned 16 times (4 runs per session, 2 sessions per day, 2 separate days) in a functional magnetic resonance imaging (fMRI) study on a 3T Philips Achieva scanner. For each run, we calculated t-value and tSNR maps. To ascertain that the results were not specific to the scanner, one volunteer was scanned with four fMRI runs in a single session on the above 3T Philips scanner as well as a 3T Siemens Prisma scanner. The coefficient of variation of voxel-wise tSNR across the 16 repeats was up to 25%, while the range relative to the mean of all observations was up to 80%. The voxel-wise variability of tSNR on the two different scanners was similar, indicating a general issue. Despite its use in evaluating the quality of fMRI data, we found only a weak relationship between tSNR and t-values. There is very high variability in voxel-wise tSNR, which should be considered while planning future studies that aim to identify small and focal fMRI effects or the benefits of incremental improvement in methods.

Abstract

The aim of this study was to evaluate the reproducibility of voxel-wise temporal signal-to-noise ratio (tSNR) on repeated scans across runs, sessions, and days. A group of 21 participants was scanned 16 times (4 runs per session, 2 sessions per day, 2 separate days) in a functional magnetic resonance imaging (fMRI) study on a 3T Philips Achieva scanner. For each run, we calculated t-value and tSNR maps. To ascertain that the results were not specific to the scanner, one volunteer was scanned with four fMRI runs in a single session on the above 3T Philips scanner as well as a 3T Siemens Prisma scanner. The coefficient of variation of voxel-wise tSNR across the 16 repeats was up to 25%, while the range relative to the mean of all observations was up to 80%. The voxel-wise variability of tSNR on the two different scanners was similar, indicating a general issue. Despite its use in evaluating the quality of fMRI data, we found only a weak relationship between tSNR and t-values. There is very high variability in voxel-wise tSNR, which should be considered while planning future studies that aim to identify small and focal fMRI effects or the benefits of incremental improvement in methods.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Scopus Subject Areas:Physical Sciences > Electronic, Optical and Magnetic Materials
Physical Sciences > Software
Physical Sciences > Computer Vision and Pattern Recognition
Physical Sciences > Electrical and Electronic Engineering
Uncontrolled Keywords:fMRI, quality assurance, reliability, reproducibility, temporal SNR
Language:English
Date:1 December 2021
Deposited On:25 Aug 2021 10:43
Last Modified:27 Jan 2024 02:38
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0899-9457
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1002/ima.22617
Project Information:
  • : FunderSNSF
  • : Grant ID32003B_166566
  • : Project TitleEnhancing functional connectivity in prefrontal networks to test and improve self-control mechanisms in decision-making
  • : FunderFP7
  • : Grant ID607310
  • : Project TitleNUDGE-IT - The Neurobiology of Decision-Making in Eating - Innovative Tools
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)