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Associations between negative symptoms and effort discounting in patients with schizophrenia and major depressive disorder


Cathomas, Flurin; Klaus, Federica; Guetter, Karoline; Seifritz, Erich; Hartmann-Riemer, Matthias N; Tobler, Philippe N; Kaiser, Stefan; Kaliuzhna, Mariia (2021). Associations between negative symptoms and effort discounting in patients with schizophrenia and major depressive disorder. Schizophrenia Bulletin, 2(1):Epub ahead of print.

Abstract

Deficits in goal-directed decision making and motivation are hallmark characteristics of several neuropsychiatric disorders, including schizophrenia (SZ) and major depressive disorder (MDD). Studies using effort-based decision-making tasks have shown that both patients with SZ and MDD invest less physical effort in order to obtain rewards. However, how these motivational deficits relate to clinically assessed symptom dimensions such as apathy remains controversial. Using a grip-strength-based effort discounting task we assessed effort-based decision-making behavior in healthy controls (HC) (N = 18), patients with SZ (N = 42), and MDD (N = 44). We then investigated how effort discounting relates to different symptom dimensions. There were no differences in effort discounting between HC participants and patients with SZ or MDD. In addition, we did not observe a correlation between effort discounting and negative symptoms (NS) in patients with SZ or MDD. In conclusion, the current study does not support an association between effort discounting and NS in SZ or MDD. Further studies are needed to investigate effort discounting and its relation to psychopathological dimensions across different neuropsychiatric disorders.

Abstract

Deficits in goal-directed decision making and motivation are hallmark characteristics of several neuropsychiatric disorders, including schizophrenia (SZ) and major depressive disorder (MDD). Studies using effort-based decision-making tasks have shown that both patients with SZ and MDD invest less physical effort in order to obtain rewards. However, how these motivational deficits relate to clinically assessed symptom dimensions such as apathy remains controversial. Using a grip-strength-based effort discounting task we assessed effort-based decision-making behavior in healthy controls (HC) (N = 18), patients with SZ (N = 42), and MDD (N = 44). We then investigated how effort discounting relates to different symptom dimensions. There were no differences in effort discounting between HC participants and patients with SZ or MDD. In addition, we did not observe a correlation between effort discounting and negative symptoms (NS) in patients with SZ or MDD. In conclusion, the current study does not support an association between effort discounting and NS in SZ or MDD. Further studies are needed to investigate effort discounting and its relation to psychopathological dimensions across different neuropsychiatric disorders.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Uncontrolled Keywords:schizophrenia, major depressive disorder, effort discounting, negative symptoms
Language:English
Date:11 June 2021
Deposited On:30 Aug 2021 15:28
Last Modified:30 Aug 2021 15:28
Publisher:Oxford University Press
ISSN:0586-7614
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/schizbullopen/sgab022
Project Information:
  • : FunderSNSF
  • : Grant ID10001CL_169783
  • : Project TitleNeural and behavioral markers for the motivational negative symptoms of schizophrenia - a longitudinal approach

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