Header

UZH-Logo

Maintenance Infos

Receptor-Mediated Endocytosis and Differentiation in Proximal Tubule Cell Systems


Berquez, Marine; Krohn, Patrick; Luciani, Alessandro; Devuyst, Olivier (2021). Receptor-Mediated Endocytosis and Differentiation in Proximal Tubule Cell Systems. Journal of the American Society of Nephrology (JASN), 32(5):1265-1267.

Abstract

The epithelial cells lining the proximal tubule (PT) of the kidney rely on multiligand receptors and vesicular membrane pathways to efficiently reabsorb essential nutrients and low–mol wt proteins (Figure 1A).1 The endolysosome stands at the crossroads of this network, processing incoming solutes, sorting receptors and/or transporters, and regulating balance between proliferation and differentiation in PT cells, hence their role in homeostasis.2,3 A major concern is to use PT cell systems that recapitulate these crucial properties, which are relevant for congenital and acquired disorders targeting the PT.

Abstract

The epithelial cells lining the proximal tubule (PT) of the kidney rely on multiligand receptors and vesicular membrane pathways to efficiently reabsorb essential nutrients and low–mol wt proteins (Figure 1A).1 The endolysosome stands at the crossroads of this network, processing incoming solutes, sorting receptors and/or transporters, and regulating balance between proliferation and differentiation in PT cells, hence their role in homeostasis.2,3 A major concern is to use PT cell systems that recapitulate these crucial properties, which are relevant for congenital and acquired disorders targeting the PT.

Statistics

Citations

Dimensions.ai Metrics
1 citation in Web of Science®
1 citation in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 13 Sep 2021
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Nephrology
Uncontrolled Keywords:Nephrology, General Medicine
Language:English
Date:3 May 2021
Deposited On:13 Sep 2021 14:59
Last Modified:14 Sep 2021 20:00
Publisher:American Society of Nephrology
ISSN:1046-6673
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1681/asn.2021020253
Project Information:
  • : FunderSNSF
  • : Grant ID310030_189044
  • : Project TitleUromodulin: from physiology to genetic susceptibility to disease
  • : FunderNational Center of Competence in Research Affective Sciences - Emotions in Individual Behaviour and Social Processes
  • : Grant ID
  • : Project Title
  • : FunderKidney Control of Homeostasis
  • : Grant ID
  • : Project Title

Download

Closed Access: Download allowed only for UZH members