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The role of microglia in neuropsychiatric disorders and suicide

Brisch, Ralf; Wojtylak, Szymon; Saniotis, Arthur; Steiner, Johann; Gos, Tomasz; Kumaratilake, Jaliya; Henneberg, Maciej; Wolf, Rainer (2022). The role of microglia in neuropsychiatric disorders and suicide. European Archives of Psychiatry and Clinical Neuroscience, 272(6):929-945.

Abstract

This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Evolutionary Medicine
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Psychiatry and Mental Health
Life Sciences > Biological Psychiatry
Health Sciences > Pharmacology (medical)
Uncontrolled Keywords:Pharmacology (medical), Biological Psychiatry, Psychiatry and Mental health, General Medicine
Language:English
Date:1 September 2022
Deposited On:18 Oct 2021 14:34
Last Modified:26 Oct 2024 01:37
Publisher:Springer
ISSN:0940-1334
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s00406-021-01334-z
PubMed ID:34595576
Project Information:
  • Funder: Hochschule Fulda
  • Grant ID:
  • Project Title:
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  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)

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