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Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease

Giroud, Nathalie; Pichora-Fuller, M K; Mick, P; Wittich, W; Al-Yawer, F; Rehan, S; Orange, J B; Phillips, N A (2021). Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease. Aging Brain, 1:100018.

Abstract

Using data from the COMPASS-ND study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s dementia (AD). SCD participants with greater pure-tone hearing loss exhibited lower hippocampal volume, but more cortical thickness in the left superior temporal gyrus and right pars opercularis. Greater speech-in-noise reception thresholds were associated with lower cortical thickness bilaterally across much of the cortex in AD. The AD group also showed a trend towards worse speech-in-noise thresholds compared to the SCD group.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Computational Linguistics
06 Faculty of Arts > Zurich Center for Linguistics
06 Faculty of Arts > Linguistic Research Infrastructure (LiRI)
Dewey Decimal Classification:000 Computer science, knowledge & systems
410 Linguistics
Uncontrolled Keywords:General Earth and Planetary Sciences, General Environmental Science
Language:English
Date:1 January 2021
Deposited On:21 Oct 2021 16:50
Last Modified:25 Nov 2024 02:38
Publisher:Elsevier
ISSN:2589-9589
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.nbas.2021.100018
Project Information:
  • Funder: SNSF
  • Grant ID: P2ZHP1_174865
  • Project Title: The Sensory and Cognitive Interface in Mild Cognitively Impaired Older Adults As Revealed By Multimodal Neuroimaging
  • Funder: SNSF
  • Grant ID: P2ZHP1_174865
  • Project Title: The Sensory and Cognitive Interface in Mild Cognitively Impaired Older Adults As Revealed By Multimodal Neuroimaging
  • Funder: SNSF
  • Grant ID: P2ZHP1_174865
  • Project Title: The Sensory and Cognitive Interface in Mild Cognitively Impaired Older Adults As Revealed By Multimodal Neuroimaging
  • Funder: SNSF
  • Grant ID: P2ZHP1_174865
  • Project Title: The Sensory and Cognitive Interface in Mild Cognitively Impaired Older Adults As Revealed By Multimodal Neuroimaging
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  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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