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Breath Sensors for Health Monitoring


Güntner, Andreas T; Abegg, Sebastian; Königstein, Karsten; Gerber, Philipp A; Schmidt-Trucksäss, Arno; Pratsinis, Sotiris E (2019). Breath Sensors for Health Monitoring. ACS Sensors, 4(2):268-280.

Abstract

Breath sensors can revolutionize medical diagnostics by on-demand detection and monitoring of health parameters in a noninvasive and personalized fashion. Despite extensive research for more than two decades, however, only a few breath sensors have been translated into clinical practice. Actually, most never even left the scientific laboratories. Here, we describe key challenges that currently impede realization of breath sensors and highlight strategies to overcome them. Specifically, we start with breath marker selection (with emphasis on metabolic and inflammatory markers) and breath sampling. Next, the sensitivity, stability, and selectivity requirements for breath sensors are described. Concepts are elaborated to systematically address these requirements by material design (focusing on chemoresistive metal oxides), orthogonal arrays, and filters. Finally, aspects of portable device integration, user communication, and clinical applicability are discussed.

Abstract

Breath sensors can revolutionize medical diagnostics by on-demand detection and monitoring of health parameters in a noninvasive and personalized fashion. Despite extensive research for more than two decades, however, only a few breath sensors have been translated into clinical practice. Actually, most never even left the scientific laboratories. Here, we describe key challenges that currently impede realization of breath sensors and highlight strategies to overcome them. Specifically, we start with breath marker selection (with emphasis on metabolic and inflammatory markers) and breath sampling. Next, the sensitivity, stability, and selectivity requirements for breath sensors are described. Concepts are elaborated to systematically address these requirements by material design (focusing on chemoresistive metal oxides), orthogonal arrays, and filters. Finally, aspects of portable device integration, user communication, and clinical applicability are discussed.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > Bioengineering
Physical Sciences > Instrumentation
Physical Sciences > Process Chemistry and Technology
Physical Sciences > Fluid Flow and Transfer Processes
Language:English
Date:22 February 2019
Deposited On:28 Oct 2021 07:16
Last Modified:27 Jan 2022 08:23
Publisher:American Chemical Society (ACS)
ISSN:2379-3694
OA Status:Closed
Publisher DOI:https://doi.org/10.1021/acssensors.8b00937
PubMed ID:30623644
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