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Primary bone augmentation leads to equally stable marginal tissue conditions comparing the use of xenograft blocks infused with BMP-2 and autogenous bone blocks: A 3D analysis after 3 years


Bienz, Stefan P; Payer, Michael; Hjerppe, Jenni; Hüsler, Jürg; Jakse, Norbert; Schmidlin, Patrick R; Hämmerle, Christoph H F; Jung, Ronald E; Thoma, Daniel S (2021). Primary bone augmentation leads to equally stable marginal tissue conditions comparing the use of xenograft blocks infused with BMP-2 and autogenous bone blocks: A 3D analysis after 3 years. Clinical Oral Implants Research, 32(12):1433-1443.

Abstract

OBJECTIVES
To test whether or not primary bone augmentation using xenograft blocks infused with BMP-2 or autogenous bone blocks lead to similar results regarding the implant survival and 3D marginal soft tissue contours.
METHODS
Twenty-four patients with an insufficient ridge width for implant placement in need of primary augmentation were randomly assigned to either a block of deproteinized bovine bone mineral infused with rhBMP-2 (BMP) or an intraorally harvested block of autogenous bone (ABB). At 4 months, 1-4 dental implants were placed in the regenerated area. After crown insertion and at 3 years, peri-implant tissue parameters, two- and three-dimensional radiographic parameters, and soft tissue contour changes were evaluated. Explorative mixed model analyses were performed. The level of significance was set at 5%.
RESULTS
At the 3-year follow-up, 23 patients with 40 implants were evaluated. The implant survival rate was 100% in both groups. At baseline, the marginal hard tissue levels amounted to -0.4 ± 0.8 mm (mean ± standard deviation) in the BMP group and -0.7 ± 1.0 mm in the ABB group. At 3 years, these values were -0.2 ± 0.4 mm (BMP) and -0.6 ± 1.0 mm (ABB). At baseline, the thickness of the buccal hard tissue at the level of the implant shoulder measured 1.1 ± 1.1 mm (BMP) and 1.4 ± 1.0 mm (ABB). At 3 years, it measured 0.9 ± 0.9 mm (BMP) and 0.7 ± 0.6 mm (ABB).
CONCLUSIONS
The present study demonstrated excellent implant survival rates and stable marginal hard tissue levels in both augmentation groups, 3 years after crown insertion. In addition, the clinical stability of soft and hard tissues was demonstrated in both groups.

Abstract

OBJECTIVES
To test whether or not primary bone augmentation using xenograft blocks infused with BMP-2 or autogenous bone blocks lead to similar results regarding the implant survival and 3D marginal soft tissue contours.
METHODS
Twenty-four patients with an insufficient ridge width for implant placement in need of primary augmentation were randomly assigned to either a block of deproteinized bovine bone mineral infused with rhBMP-2 (BMP) or an intraorally harvested block of autogenous bone (ABB). At 4 months, 1-4 dental implants were placed in the regenerated area. After crown insertion and at 3 years, peri-implant tissue parameters, two- and three-dimensional radiographic parameters, and soft tissue contour changes were evaluated. Explorative mixed model analyses were performed. The level of significance was set at 5%.
RESULTS
At the 3-year follow-up, 23 patients with 40 implants were evaluated. The implant survival rate was 100% in both groups. At baseline, the marginal hard tissue levels amounted to -0.4 ± 0.8 mm (mean ± standard deviation) in the BMP group and -0.7 ± 1.0 mm in the ABB group. At 3 years, these values were -0.2 ± 0.4 mm (BMP) and -0.6 ± 1.0 mm (ABB). At baseline, the thickness of the buccal hard tissue at the level of the implant shoulder measured 1.1 ± 1.1 mm (BMP) and 1.4 ± 1.0 mm (ABB). At 3 years, it measured 0.9 ± 0.9 mm (BMP) and 0.7 ± 0.6 mm (ABB).
CONCLUSIONS
The present study demonstrated excellent implant survival rates and stable marginal hard tissue levels in both augmentation groups, 3 years after crown insertion. In addition, the clinical stability of soft and hard tissues was demonstrated in both groups.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic of Conservative and Preventive Dentistry
04 Faculty of Medicine > Center for Dental Medicine > Clinic of Reconstructive Dentistry
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oral Surgery
Language:English
Date:1 December 2021
Deposited On:28 Oct 2021 13:20
Last Modified:26 Apr 2024 01:35
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0905-7161
Additional Information:This is the peer reviewed version of the following article: Bienz, Stefan P; Payer, Michael; Hjerppe, Jenni; Hüsler, Jürg; Jakse, Norbert; Schmidlin, Patrick R; Hämmerle, Christoph H F; Jung, Ronald E; Thoma, Daniel S (2021). Primary bone augmentation leads to equally stable marginal tissue conditions comparing the use of xenograft blocks infused with BMP-2 and autogenous bone blocks: A 3D analysis after 3 years. Clinical Oral Implants Research:Online ahead of print, which has been published in final form at https://doi.org/ 10.1111/clr.13843. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. (http://www.wileyauthors.com/self-archiving)
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/clr.13843
PubMed ID:34543475
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)