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Rapid and reversible control of human metabolism by individual sleep states

Nowak, Nora; Gaisl, Thomas; Miladinovic, Djordje; Marcinkevics, Ricards; Osswald, Martin; Bauer, Stefan; Buhmann, Joachim; Zenobi, Renato; Sinues, Pablo; Brown, Steven A; Kohler, Malcolm (2021). Rapid and reversible control of human metabolism by individual sleep states. Cell Reports, 37(4):109903.

Abstract

Sleep is crucial to restore body functions and metabolism across nearly all tissues and cells, and sleep restriction is linked to various metabolic dysfunctions in humans. Using exhaled breath analysis by secondary electrospray ionization high-resolution mass spectrometry, we measured the human exhaled metabolome at 10-s resolution across a night of sleep in combination with conventional polysomnography. Our subsequent analysis of almost 2,000 metabolite features demonstrates rapid, reversible control of major metabolic pathways by the individual vigilance states. Within this framework, whereas a switch to wake reduces fatty acid oxidation, a switch to slow-wave sleep increases it, and the transition to rapid eye movement sleep results in elevation of tricarboxylic acid (TCA) cycle intermediates. Thus, in addition to daily regulation of metabolism, there exists a surprising and complex underlying orchestration across sleep and wake. Both likely play an important role in optimizing metabolic circuits for human performance and health.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
07 Faculty of Science > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:General Biochemistry, Genetics and Molecular Biology
Language:English
Date:1 October 2021
Deposited On:02 Nov 2021 09:45
Last Modified:26 Jan 2025 02:35
Publisher:Cell Press (Elsevier)
ISSN:2211-1247
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.celrep.2021.109903
PubMed ID:34706242
Project Information:
  • Funder: Velux Stiftung
  • Grant ID:
  • Project Title:
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  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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