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Dysbiotic microbiota interactions in Crohn's disease


Caparrós, Esther; Wiest, Reiner; Scharl, Michael; Rogler, Gerhard; Gutiérrez Casbas, Ana; Yilmaz, Bahtiyar; Wawrzyniak, Marcin; Francés, Rubén (2021). Dysbiotic microbiota interactions in Crohn's disease. Gut Microbes, 13:e1949096.

Abstract

Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.

Abstract

Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.

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Additional indexing

Item Type:Journal Article, not_refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Microbiology
Health Sciences > Gastroenterology
Health Sciences > Microbiology (medical)
Health Sciences > Infectious Diseases
Language:English
Date:30 December 2021
Deposited On:08 Nov 2021 07:34
Last Modified:25 Jun 2024 01:47
Publisher:Taylor & Francis
ISSN:1949-0976
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/19490976.2021.1949096
PubMed ID:34313550
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)