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LSD and ketanserin and their impact on the human autonomic nervous system


Olbrich, Sebastian; Preller, Katrin H; Vollenweider, Franz X (2021). LSD and ketanserin and their impact on the human autonomic nervous system. Psychophysiology, 58(6):e13822.

Abstract

The interest in lysergic acid diethylamide (LSD) has sparked again due to its supposed positive effects on psychopathological conditions. Yet, most research focuses on the actions of LSD on the central nervous system. The interaction with the autonomic nervous system (ANS) has been neglected so far. Therefore, the aim was to assess the effects of LSD and the serotonin 2A receptor antagonist ketanserin on the ANS as assessed by heart rate variability (HRV) measures and their correlation with subjective drug-induced effects in a randomized, placebo-controlled crossover trial. Thus, ANS activity was derived from electrocardiogram recordings after intake of placebo, LSD or ketanserin, and LSD by calculating R-peak-based measures of sympathetic and parasympathetic activity. Repeated measure ANOVA and partial correlation for HRV measures and subjective experience questionnaires were performed. LSD predominantly increased sympathetic activity, while ketanserin counteracted this effect on the ANS via an increase of parasympathetic tone. Sympathetic activity was positively and parasympathetic activity negatively associated with psychedelic effects of LSD. Furthermore, Placebo HRV measures predicted subjective experiences after LSD intake. The association between trait ANS activity and LSD-induced subjective experiences may serve as a candidate biomarker set for the effectiveness of LSD in the treatment of psychopathological conditions.

Abstract

The interest in lysergic acid diethylamide (LSD) has sparked again due to its supposed positive effects on psychopathological conditions. Yet, most research focuses on the actions of LSD on the central nervous system. The interaction with the autonomic nervous system (ANS) has been neglected so far. Therefore, the aim was to assess the effects of LSD and the serotonin 2A receptor antagonist ketanserin on the ANS as assessed by heart rate variability (HRV) measures and their correlation with subjective drug-induced effects in a randomized, placebo-controlled crossover trial. Thus, ANS activity was derived from electrocardiogram recordings after intake of placebo, LSD or ketanserin, and LSD by calculating R-peak-based measures of sympathetic and parasympathetic activity. Repeated measure ANOVA and partial correlation for HRV measures and subjective experience questionnaires were performed. LSD predominantly increased sympathetic activity, while ketanserin counteracted this effect on the ANS via an increase of parasympathetic tone. Sympathetic activity was positively and parasympathetic activity negatively associated with psychedelic effects of LSD. Furthermore, Placebo HRV measures predicted subjective experiences after LSD intake. The association between trait ANS activity and LSD-induced subjective experiences may serve as a candidate biomarker set for the effectiveness of LSD in the treatment of psychopathological conditions.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Social Sciences & Humanities > Neuropsychology and Physiological Psychology
Social Sciences & Humanities > Experimental and Cognitive Psychology
Life Sciences > Neurology
Life Sciences > Endocrine and Autonomic Systems
Life Sciences > Developmental Neuroscience
Life Sciences > Cognitive Neuroscience
Life Sciences > Biological Psychiatry
Uncontrolled Keywords:Experimental and Cognitive Psychology, Neuropsychology and Physiological Psychology, Biological Psychiatry, Cognitive Neuroscience, Developmental Neuroscience, Endocrine and Autonomic Systems, Neurology, General Neuroscience
Language:English
Date:1 June 2021
Deposited On:07 Dec 2021 07:24
Last Modified:26 Apr 2024 01:37
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0048-5772
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/psyp.13822
PubMed ID:33772794