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Cutaneous SCC with orbital invasion: case series


Nägeli, M; Mangana, J; Chaloupka, K; Dummer, Reinhard (2022). Cutaneous SCC with orbital invasion: case series. Journal of the European Academy of Dermatology and Venerology, 36(S1):59-62.

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the most common tumour entity that grows secondarily into the orbital area, while basal cell carcinoma (BCC) is the most common periocular and eyelid tumour. Diagnostic delays are common and may increase post-treatment complications. The therapy is challenging and must be discussed at an interdisciplinary tumour board. We discuss four cases of cSCC with orbital invasion treated with immune-checkpoint inhibitors with variable responses.
What does this study add?
- cSCC is the most common tumour entity that grows secondarily into the orbital area
- Diagnosis often may be delayed due to vague complaints
- Numbness and pain were the most common symptoms
- A rapid response rate is usually seen with anti-PD1 therapy

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the most common tumour entity that grows secondarily into the orbital area, while basal cell carcinoma (BCC) is the most common periocular and eyelid tumour. Diagnostic delays are common and may increase post-treatment complications. The therapy is challenging and must be discussed at an interdisciplinary tumour board. We discuss four cases of cSCC with orbital invasion treated with immune-checkpoint inhibitors with variable responses.
What does this study add?
- cSCC is the most common tumour entity that grows secondarily into the orbital area
- Diagnosis often may be delayed due to vague complaints
- Numbness and pain were the most common symptoms
- A rapid response rate is usually seen with anti-PD1 therapy

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Dermatology
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Infectious Diseases, Dermatology
Language:English
Date:1 January 2022
Deposited On:10 Dec 2021 05:30
Last Modified:26 Jun 2024 01:46
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0926-9959
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1111/jdv.17529
PubMed ID:34855245
  • Content: Published Version
  • Licence: Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)