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When Secretomes Meet Anthelmintics: Lessons for Therapeutic Interventions


Moreno, Yovany; Geary, Timothy G; Tritten, Lucienne (2021). When Secretomes Meet Anthelmintics: Lessons for Therapeutic Interventions. Trends in Parasitology, 37(6):468-475.

Abstract

Helminth secretomes comprise many potential immunomodulators. The molecular and functional diversity of these entities and their importance at the host-parasite interface have been increasingly recognized. It is now common to hypothesize that parasite-derived molecules (PDMs) are essential mediators used by parasites to establish and remain in their hosts. Suppression of PDM release has been reported for two anthelmintic drug classes, the benzimidazoles and macrocyclic lactones, the mechanisms of action of which remain incompletely resolved. We propose that bringing together recent insights from different streams of parasitology research, for example, immunoparasitology and pharmacology, will stimulate the development of new ways to alter the host-parasite interface in the search for novel anthelmintic strategies.

Abstract

Helminth secretomes comprise many potential immunomodulators. The molecular and functional diversity of these entities and their importance at the host-parasite interface have been increasingly recognized. It is now common to hypothesize that parasite-derived molecules (PDMs) are essential mediators used by parasites to establish and remain in their hosts. Suppression of PDM release has been reported for two anthelmintic drug classes, the benzimidazoles and macrocyclic lactones, the mechanisms of action of which remain incompletely resolved. We propose that bringing together recent insights from different streams of parasitology research, for example, immunoparasitology and pharmacology, will stimulate the development of new ways to alter the host-parasite interface in the search for novel anthelmintic strategies.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Parasitology
04 Faculty of Medicine > Institute of Parasitology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
600 Technology
Scopus Subject Areas:Life Sciences > Parasitology
Health Sciences > Infectious Diseases
Uncontrolled Keywords:Infectious Diseases, Parasitology
Language:English
Date:1 June 2021
Deposited On:25 Dec 2021 12:49
Last Modified:26 Jun 2024 01:46
Publisher:Elsevier
ISSN:1471-4922
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.pt.2021.01.007
Project Information:
  • : FunderNatural Sciences and Engineering Research Council of Canada
  • : Grant ID
  • : Project Title
  • : FunderSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)