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Influence of radiation dose and reconstruction kernel on fat fraction analysis in dual-energy CT: A phantom study

Chatzaraki, Vasiliki; Born, Corinna; Kubik-Huch, Rahel A; Froehlich, Johannes M; Thali, Michael J; Niemann, Tilo (2021). Influence of radiation dose and reconstruction kernel on fat fraction analysis in dual-energy CT: A phantom study. In Vivo, 35(6):3147-3155.

Abstract

Background/Aim: The quantitative evaluation of fat tissue, mainly for the determination of liver steatosis, is possible by using dual-energy computed tomography. Different photon energy acquisitions allow for estimation of attenuation coefficients. The effect of variation in radiation doses and reconstruction kernels on fat fraction estimation was investigated. Materials and Methods: A six-probe-phantom with fat concentrations of 0%, 20%, 40%, 60%, 80%, and 100% were scanned in Sn140/100 kV with radiation doses ranging between 20 and 200 mAs before and after calibration. Images were reconstructed using iterative kernels (I26,Q30,I70). Results: Fat fractions measured in dual-energy computed tomography (DECT) were consistent with the 20%-stepwise varying actual concentrations. Variation in radiation dose resulted in 3.1% variation of fat fraction. Softer reconstruction kernel (I26) underestimated the fat fraction (–9.1%), while quantitative (Q30) and sharper kernel (I70) overestimated fat fraction (10,8% and 13,1, respectively). Conclusion: The fat fraction in DECT approaches the actual fat concentration when calibrated to the reconstruction kerneö. Variation of radiation dose caused an acceptable 3% variation.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
510 Mathematics
Scopus Subject Areas:Life Sciences > General Biochemistry, Genetics and Molecular Biology
Life Sciences > Pharmacology
Uncontrolled Keywords:Pharmacology, General Biochemistry, Genetics and Molecular Biology, Cancer Research
Language:English
Date:1 January 2021
Deposited On:20 Dec 2021 10:07
Last Modified:26 Oct 2024 01:40
Publisher:International Institute of Anticancer Research
ISSN:0258-851X
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.21873/invivo.12609
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  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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