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Fourier Transform of Percoll Gradients Boosts CNN Classification of Hereditary Hemolytic Anemias

Sadafi, Ario; Sans, Lucia Maria Moya; Makhro, Asya; Livshits, Leonid; Navab, Nassir; Bogdanova, Anna; Albarqouni, Shadi; Marr, Carsten (2021). Fourier Transform of Percoll Gradients Boosts CNN Classification of Hereditary Hemolytic Anemias. In: 2021 IEEE 18th International Symposium on Biomedical Imaging (ISBI), Nice, France, 13 April 2021 - 16 April 2021. IEEE, 1-5.

Abstract

Hereditary hemolytic anemias are genetic disorders that af-fect the shape and density of red blood cells. Genetic testscurrently used to diagnose such anemias are expensive andunavailable in the majority of clinical labs. Here, we pro-pose a method for identifying hereditary hemolytic anemiasbased on a standard biochemistry method, called Percollgradient, obtained by centrifuging a patient’s blood. Our hy-brid approach consists on using spatial data-driven features,extracted with a convolutional neural network and spectralhandcrafted features obtained from fast Fourier transform.We compare late and early feature fusion with AlexNet andVGG16 architectures. AlexNet with late fusion of spectralfeatures performs better compared to other approaches. Weachieved an average F1-score of 88% on different classes sug-gesting the possibility of diagnosing of hereditary hemolyticanemias from Percoll gradients. Finally, we utilize Grad-CAM to explore the spatial features used for classification.

Additional indexing

Item Type:Conference or Workshop Item (Paper), not_refereed, original work
Communities & Collections:04 Faculty of Medicine > Zurich Center for Integrative Human Physiology (ZIHP)
05 Vetsuisse Faculty > Veterinärwissenschaftliches Institut > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Physical Sciences > Biomedical Engineering
Health Sciences > Radiology, Nuclear Medicine and Imaging
Language:English
Event End Date:16 April 2021
Deposited On:25 Dec 2021 13:04
Last Modified:19 Feb 2024 11:11
Publisher:IEEE
OA Status:Green
Publisher DOI:https://doi.org/10.1109/isbi48211.2021.9433788
Project Information:
  • Funder: H2020
  • Grant ID: 675115
  • Project Title: Regulation of red cell life-span, erythropoiesis, survival, senescence and clearance
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