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Heritable responses to combined effects of heat stress and ivermectin in the yellow dung fly


González-Tokman, Daniel; Bauerfeind, Stephanie S; Schäfer, Martin A; Walters, Richard J; Berger, David; Blanckenhorn, Wolf U (2022). Heritable responses to combined effects of heat stress and ivermectin in the yellow dung fly. Chemosphere, 286:131030.

Abstract

In current times of global change, several sources of stress such as contaminants and high temperatures may act synergistically. The extent to which organisms persist in stressful conditions will depend on the fitness consequences of multiple simultaneously acting stressors and the genetic basis of compensatory genetic responses. Ivermectin is an antiparasitic drug used in livestock that is excreted in dung of treated cattle, causing severe negative consequences on non-target fauna. We evaluated the effect of a combination of heat stress and exposure to ivermectin in the yellow dung fly, Scathophaga stercoraria (Diptera: Scathophagidae). In a first experiment we investigated the effects of high rearing temperature on susceptibility to ivermectin, and in a second experiment we assayed flies from a latitudinal gradient to assess potential effects of local thermal adaptation on ivermectin sensitivity. The combination of heat and ivermectin synergistically reduced offspring survival, revealing severe effects of the two stressors when combined. However, latitudinal populations did not systematically vary in how ivermectin affected offspring survival, body size, development time, cold and heat tolerance. We also found very low narrow-sense heritability of ivermectin sensitivity, suggesting evolutionary constraints for responses to the combination of these stressors beyond immediate maternal or plastic effects. If the revealed patterns hold also for other invertebrates, the combination of increasing climate warming and ivermectin stress may thus have severe consequences for biodiversity. More generally, our study underlines the need for quantitative genetic analyses in understanding wildlife responses to interacting stressors that act synergistically and threat biodiversity.

Abstract

In current times of global change, several sources of stress such as contaminants and high temperatures may act synergistically. The extent to which organisms persist in stressful conditions will depend on the fitness consequences of multiple simultaneously acting stressors and the genetic basis of compensatory genetic responses. Ivermectin is an antiparasitic drug used in livestock that is excreted in dung of treated cattle, causing severe negative consequences on non-target fauna. We evaluated the effect of a combination of heat stress and exposure to ivermectin in the yellow dung fly, Scathophaga stercoraria (Diptera: Scathophagidae). In a first experiment we investigated the effects of high rearing temperature on susceptibility to ivermectin, and in a second experiment we assayed flies from a latitudinal gradient to assess potential effects of local thermal adaptation on ivermectin sensitivity. The combination of heat and ivermectin synergistically reduced offspring survival, revealing severe effects of the two stressors when combined. However, latitudinal populations did not systematically vary in how ivermectin affected offspring survival, body size, development time, cold and heat tolerance. We also found very low narrow-sense heritability of ivermectin sensitivity, suggesting evolutionary constraints for responses to the combination of these stressors beyond immediate maternal or plastic effects. If the revealed patterns hold also for other invertebrates, the combination of increasing climate warming and ivermectin stress may thus have severe consequences for biodiversity. More generally, our study underlines the need for quantitative genetic analyses in understanding wildlife responses to interacting stressors that act synergistically and threat biodiversity.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Scopus Subject Areas:Physical Sciences > Environmental Engineering
Physical Sciences > General Chemistry
Physical Sciences > Environmental Chemistry
Physical Sciences > Pollution
Health Sciences > Public Health, Environmental and Occupational Health
Physical Sciences > Health, Toxicology and Mutagenesis
Uncontrolled Keywords:General Medicine, General Chemistry, Environmental Chemistry, Environmental Engineering, Pollution, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health
Language:English
Date:1 January 2022
Deposited On:04 Jan 2022 06:52
Last Modified:26 Feb 2024 02:40
Publisher:Elsevier
ISSN:0045-6535
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.chemosphere.2021.131030
PubMed ID:34144808
Project Information:
  • : FunderFP7
  • : Grant ID257894
  • : Project TitleIMPROV - Innovative Mid-infrared high Power source for resonant ablation of Organic based photovoltaic devices
  • : FunderFP7
  • : Grant ID257894
  • : Project TitleIMPROV - Innovative Mid-infrared high Power source for resonant ablation of Organic based photovoltaic devices
  • : FunderFP7
  • : Grant ID257894
  • : Project TitleIMPROV - Innovative Mid-infrared high Power source for resonant ablation of Organic based photovoltaic devices
  • : FunderFP7
  • : Grant ID257894
  • : Project TitleIMPROV - Innovative Mid-infrared high Power source for resonant ablation of Organic based photovoltaic devices
  • : FunderFP7
  • : Grant ID257894
  • : Project TitleIMPROV - Innovative Mid-infrared high Power source for resonant ablation of Organic based photovoltaic devices
  • : FunderFP7
  • : Grant ID257894
  • : Project TitleIMPROV - Innovative Mid-infrared high Power source for resonant ablation of Organic based photovoltaic devices
  • Content: Accepted Version
  • Language: English
  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)