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Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement


Gaurav, Kumar; Arora, Sanu; Silva, Paula; et al; Sánchez-Martín, Javier; Widrig, Victoria; Keller, Beat (2022). Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement. Nature Biotechnology, 40(3):422-431.

Abstract

Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding.

Abstract

Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Plant and Microbial Biology
07 Faculty of Science > Zurich-Basel Plant Science Center
Dewey Decimal Classification:580 Plants (Botany)
Scopus Subject Areas:Life Sciences > Biotechnology
Physical Sciences > Bioengineering
Life Sciences > Applied Microbiology and Biotechnology
Life Sciences > Molecular Medicine
Physical Sciences > Biomedical Engineering
Uncontrolled Keywords:Biomedical Engineering, Molecular Medicine, Applied Microbiology and Biotechnology, Bioengineering, Biotechnology
Language:English
Date:1 March 2022
Deposited On:07 Jan 2022 08:14
Last Modified:28 Jan 2024 02:39
Publisher:Nature Publishing Group
ISSN:1087-0156
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/s41587-021-01058-4
PubMed ID:34725503
Project Information:
  • : FunderFulbright Association
  • : Grant ID
  • : Project Title
  • : FunderUnited States Department of Agriculture | National Institute of Food and Agriculture
  • : Grant ID
  • : Project Title
  • : FunderKementerian Riset, Teknologi dan Pendidikan Tinggi
  • : Grant ID
  • : Project Title
  • : FunderU.S. Department of Agriculture
  • : Grant ID
  • : Project Title
  • : FunderSNSF
  • : Grant ID310030B_182833
  • : Project TitleMolecular analysis of disease resistance specificity in cereals
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)