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Dissociating breathlessness symptoms from mood in asthma


Harrison, Olivia K; Marlow, Lucy; Finnegan, Sarah L; Ainsworth, Ben; Pattinson, Kyle T S (2021). Dissociating breathlessness symptoms from mood in asthma. Biological Psychology, 165:108193.

Abstract

It is poorly understood why asthma symptoms are often discordant with objective medical tests. Differences in interoception (perception of internal bodily processes) may help explain symptom discordance, which may be further influenced by mood and attention. We explored inter-relationships between interoception, mood and attention in 63 individuals with asthma and 30 controls. Questionnaires, a breathing-related interoception task, two attention tasks, and standard clinical assessments were performed. Questionnaires were analysed using exploratory factor analysis, and linear regression examined relationships between measures. K-means clustering also defined asthma subgroups. Two concordant asthma subgroups (symptoms related appropriately to pathophysiology, normal mood) and one discordant subgroup (moderate symptoms, minor pathophysiology, low mood) were found. In all participants, negative mood correlated with decreased interoceptive ability and faster reaction times in an attention task. Our findings suggest that interpreting bodily sensations relates to mood, and this effect may be heightened in subgroups of individuals with asthma.

Abstract

It is poorly understood why asthma symptoms are often discordant with objective medical tests. Differences in interoception (perception of internal bodily processes) may help explain symptom discordance, which may be further influenced by mood and attention. We explored inter-relationships between interoception, mood and attention in 63 individuals with asthma and 30 controls. Questionnaires, a breathing-related interoception task, two attention tasks, and standard clinical assessments were performed. Questionnaires were analysed using exploratory factor analysis, and linear regression examined relationships between measures. K-means clustering also defined asthma subgroups. Two concordant asthma subgroups (symptoms related appropriately to pathophysiology, normal mood) and one discordant subgroup (moderate symptoms, minor pathophysiology, low mood) were found. In all participants, negative mood correlated with decreased interoceptive ability and faster reaction times in an attention task. Our findings suggest that interpreting bodily sensations relates to mood, and this effect may be heightened in subgroups of individuals with asthma.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Social Sciences & Humanities > Neuropsychology and Physiological Psychology
Uncontrolled Keywords:Neuropsychology and Physiological Psychology, General Neuroscience
Language:English
Date:1 October 2021
Deposited On:07 Jan 2022 14:43
Last Modified:27 Nov 2023 02:41
Publisher:Elsevier
ISSN:0301-0511
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.biopsycho.2021.108193
PubMed ID:34560173
Project Information:
  • : FunderH2020
  • : Grant ID793580
  • : Project TitleILBAB - The interoceptive link between anxiety and breathing perception
  • : FunderJabbs Foundation
  • : Grant ID
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  • : FunderRoyal Society Te Apārangi
  • : Grant ID
  • : Project Title
  • : FunderHorizon 2020
  • : Grant ID
  • : Project Title
  • : FunderNational Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)