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2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics


Jiang, Jingjing; Di Costanzo Mata, Aldo; Lindner, Scott; Charbon, Edoardo; Wolf, Martin; Kalyanov, Alexander (2022). 2.5 Hz sample rate time-domain near-infrared optical tomography based on SPAD-camera image tissue hemodynamics. Biomedical Optics Express, 13(1):133-146.

Abstract

Time-domain near-infrared optical tomography (TD NIROT) techniques based on diffuse light were gaining performance over the last years. They are capable of imaging tissue at several centimeters depth and reveal clinically relevant information, such as tissue oxygen saturation. In this work, we present the very first in vivo results of our SPAD camera-based TD NIROT reflectance system with a temporal resolution of ∼116 ps. It provides 2800 time of flight source-detector pairs in a compact probe of only 6 cm in diameter. Additionally, we describe a 3-step reconstruction procedure that enables accurate recovery of structural information and of the optical properties. We demonstrate the system’s performance firstly in reconstructing the 3D-structure of a heterogeneous tissue phantom with tissue-like scattering and absorption properties within a volume of 9 cm diameter and 5 cm thickness. Furthermore, we performed in vivo tomography of an index finger located within a homogeneous scattering medium. We employed a fast sampling rate of 2.5 Hz to detect changes in tissue oxygenation. Tomographic reconstructions were performed in true 3D, and without prior structural information, demonstrating the powerful capabilities of the system. This shows its potential for clinical applications.

Abstract

Time-domain near-infrared optical tomography (TD NIROT) techniques based on diffuse light were gaining performance over the last years. They are capable of imaging tissue at several centimeters depth and reveal clinically relevant information, such as tissue oxygen saturation. In this work, we present the very first in vivo results of our SPAD camera-based TD NIROT reflectance system with a temporal resolution of ∼116 ps. It provides 2800 time of flight source-detector pairs in a compact probe of only 6 cm in diameter. Additionally, we describe a 3-step reconstruction procedure that enables accurate recovery of structural information and of the optical properties. We demonstrate the system’s performance firstly in reconstructing the 3D-structure of a heterogeneous tissue phantom with tissue-like scattering and absorption properties within a volume of 9 cm diameter and 5 cm thickness. Furthermore, we performed in vivo tomography of an index finger located within a homogeneous scattering medium. We employed a fast sampling rate of 2.5 Hz to detect changes in tissue oxygenation. Tomographic reconstructions were performed in true 3D, and without prior structural information, demonstrating the powerful capabilities of the system. This shows its potential for clinical applications.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Biotechnology
Physical Sciences > Atomic and Molecular Physics, and Optics
Uncontrolled Keywords:Atomic and Molecular Physics, and Optics, Biotechnology
Language:English
Date:1 January 2022
Deposited On:07 Jan 2022 15:10
Last Modified:26 Jun 2024 01:48
Publisher:Optical Society of America
ISSN:2156-7085
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1364/boe.441061
Official URL:https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-13-1-133&id=465686
PubMed ID:35154859
Project Information:
  • : FunderSNSF
  • : Grant ID200021_197079
  • : Project TitleNon-invasive accurate brain oximetry by innovative near-infrared spectroscopy (BrainOX)
  • : FunderSNSF
  • : Grant ID320030_159490
  • : Project TitleBeyond individual brain activity: Assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning
  • : FunderCentre d'Imagerie BioMédicale
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)