Abstract
Replacing an adamantyl unit in the protein kinase inhibitor Opaganib® with an integrated [(η$^{5}$-Cp)M(CO)$_{3}$] (M = Re, 99mTc) unit retains the lead's bioactivity and yields a true matched-pair pharmacomimetic.
Lengacher, Raphael; Wang, Youchao; Braband, Henrik; Blacque, Olivier; Gasser, Gilles; Alberto, Roger (2021). Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®. Chemical Communications, 57(98):13349-13352.
Abstract
Replacing an adamantyl unit in the protein kinase inhibitor Opaganib® with an integrated [(η$^{5}$-Cp)M(CO)$_{3}$] (M = Re, 99mTc) unit retains the lead's bioactivity and yields a true matched-pair pharmacomimetic.
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| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials Physical Sciences > Ceramics and Composites Physical Sciences > General Chemistry Physical Sciences > Surfaces, Coatings and Films Physical Sciences > Metals and Alloys Physical Sciences > Materials Chemistry |
| Uncontrolled Keywords: | Materials Chemistry, Metals and Alloys, Surfaces, Coatings and Films, General Chemistry, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Catalysis |
| Language: | English |
| Date: | 1 January 2021 |
| Deposited On: | 13 Jan 2022 14:39 |
| Last Modified: | 27 Sep 2022 11:43 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| OA Status: | Hybrid |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1039/d1cc03678e |
| Project Information: |
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Lengacher, Raphael