Header

UZH-Logo

Maintenance Infos

Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®


Lengacher, Raphael; Wang, Youchao; Braband, Henrik; Blacque, Olivier; Gasser, Gilles; Alberto, Roger (2021). Organometallic small molecule kinase inhibitors – direct incorporation of Re and 99mTc into Opaganib®. Chemical Communications, 57(98):13349-13352.

Abstract

Replacing an adamantyl unit in the protein kinase inhibitor Opaganib® with an integrated [(η$^{5}$-Cp)M(CO)$_{3}$] (M = Re, 99mTc) unit retains the lead's bioactivity and yields a true matched-pair pharmacomimetic.

Abstract

Replacing an adamantyl unit in the protein kinase inhibitor Opaganib® with an integrated [(η$^{5}$-Cp)M(CO)$_{3}$] (M = Re, 99mTc) unit retains the lead's bioactivity and yields a true matched-pair pharmacomimetic.

Statistics

Citations

Dimensions.ai Metrics
6 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

25 downloads since deposited on 13 Jan 2022
12 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials
Physical Sciences > Ceramics and Composites
Physical Sciences > General Chemistry
Physical Sciences > Surfaces, Coatings and Films
Physical Sciences > Metals and Alloys
Physical Sciences > Materials Chemistry
Uncontrolled Keywords:Materials Chemistry, Metals and Alloys, Surfaces, Coatings and Films, General Chemistry, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Catalysis
Language:English
Date:1 January 2021
Deposited On:13 Jan 2022 14:39
Last Modified:26 Feb 2024 02:42
Publisher:Royal Society of Chemistry
ISSN:1359-7345
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1039/d1cc03678e
Project Information:
  • : FunderUniversität Zürich
  • : Grant ID
  • : Project Title
  • Content: Published Version
  • Licence: Creative Commons: Attribution 3.0 Unported (CC BY 3.0)