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Detection of EEG burst-suppression in neurocritical care patients using an unsupervised machine learning algorithm


Narula, G; Haeberlin, M; Balsiger, J; Strässle, C; Imbach, L L; Keller, E (2021). Detection of EEG burst-suppression in neurocritical care patients using an unsupervised machine learning algorithm. Clinical Neurophysiology, 132(10):2485-2492.

Abstract

Objective: The burst suppression pattern in clinical electroencephalographic (EEG) recordings is an important diagnostic tool because of its association with comas of various etiologies, as with hypoxia, drug related intoxication or deep anesthesia. The detection of bursts and the calculation of burst/suppression ratio are often used to monitor the level of anesthesia during treatment of status epilepticus. However, manual counting of bursts is a laborious process open to inter-rater variation and motivates a need for automatic detection.

Methods: We describe a novel unsupervised learning algorithm that detects bursts in EEG and generates burst-per-minute estimates for the purpose of monitoring sedation level in an intensive care unit (ICU). We validated the algorithm on 29 hours of burst annotated EEG data from 29 patients suffering from status epilepticus and hemorrhage.

Results: We report competitive results in comparison to neural networks learned via supervised learning. The mean absolute error (SD) in bursts per minute was 0.93 (1.38).

Conclusion: We present a novel burst suppression detection algorithm that adapts to each patient individually, reports bursts-per-minute quickly, and does not require manual fine-tuning unlike previous approaches to burst-suppression pattern detection.

Significance: Our algorithm for automatic burst suppression quantification can greatly reduce manual oversight in depth of sedation monitoring.

Keywords: Burst suppression; EEG; Machine learning; Neurocritical care; Unsupervised.

Abstract

Objective: The burst suppression pattern in clinical electroencephalographic (EEG) recordings is an important diagnostic tool because of its association with comas of various etiologies, as with hypoxia, drug related intoxication or deep anesthesia. The detection of bursts and the calculation of burst/suppression ratio are often used to monitor the level of anesthesia during treatment of status epilepticus. However, manual counting of bursts is a laborious process open to inter-rater variation and motivates a need for automatic detection.

Methods: We describe a novel unsupervised learning algorithm that detects bursts in EEG and generates burst-per-minute estimates for the purpose of monitoring sedation level in an intensive care unit (ICU). We validated the algorithm on 29 hours of burst annotated EEG data from 29 patients suffering from status epilepticus and hemorrhage.

Results: We report competitive results in comparison to neural networks learned via supervised learning. The mean absolute error (SD) in bursts per minute was 0.93 (1.38).

Conclusion: We present a novel burst suppression detection algorithm that adapts to each patient individually, reports bursts-per-minute quickly, and does not require manual fine-tuning unlike previous approaches to burst-suppression pattern detection.

Significance: Our algorithm for automatic burst suppression quantification can greatly reduce manual oversight in depth of sedation monitoring.

Keywords: Burst suppression; EEG; Machine learning; Neurocritical care; Unsupervised.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Intensive Care Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Sensory Systems
Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Neurology (clinical), Neurology, Sensory Systems
Language:English
Date:1 October 2021
Deposited On:17 Jan 2022 16:32
Last Modified:26 Feb 2024 02:43
Publisher:Elsevier
ISSN:1388-2457
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.clinph.2021.07.018
PubMed ID:34454277
  • Content: Published Version
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)