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Context-Dependent Neural Activity in Mouse Motor Cortex


Sipilä, Pia. Context-Dependent Neural Activity in Mouse Motor Cortex. 2021, University of Zurich, Faculty of Science.

Abstract

Movement is essential for an animal to interact with its environment. Furthermore, the better the animal learns the specific demands of the environment, the more fluent is the motor execution. The study of motor control, and how sensorimotor integration guides motor control, is important for understanding the function of neural networks. It is known that the primary motor areas are organized in a topographical manner, but the knowledge on how environmental demands are reflected and encoded in cortical neuronal activity and how this can be shaped by learning is still limited. In my thesis work I focused on how contextual information is encoded in the mouse motor cortex, using two-photon imaging combined with a regular vs. irregular rung ladder locomotion task and across learning. I found that context-depend activity in the primary motor area M1 develops during learning, especially for highly skilled grasping actions, but breaks apart upon silencing of projections from secondary motor cortex. Furthermore, neuronal populations in secondary motor cortex M2 enable adaptive motor behavior by refining context-specific activity patterns.

Abstract

Movement is essential for an animal to interact with its environment. Furthermore, the better the animal learns the specific demands of the environment, the more fluent is the motor execution. The study of motor control, and how sensorimotor integration guides motor control, is important for understanding the function of neural networks. It is known that the primary motor areas are organized in a topographical manner, but the knowledge on how environmental demands are reflected and encoded in cortical neuronal activity and how this can be shaped by learning is still limited. In my thesis work I focused on how contextual information is encoded in the mouse motor cortex, using two-photon imaging combined with a regular vs. irregular rung ladder locomotion task and across learning. I found that context-depend activity in the primary motor area M1 develops during learning, especially for highly skilled grasping actions, but breaks apart upon silencing of projections from secondary motor cortex. Furthermore, neuronal populations in secondary motor cortex M2 enable adaptive motor behavior by refining context-specific activity patterns.

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Additional indexing

Item Type:Dissertation (cumulative)
Referees:Helmchen Fritjof, Caflisch Amedeo, Baumann Christian, Schwab Martin E
Communities & Collections:04 Faculty of Medicine > Neuroscience Center Zurich
04 Faculty of Medicine > Brain Research Institute
UZH Dissertations
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:28 October 2021
Deposited On:21 Jan 2022 11:25
Last Modified:19 Feb 2024 11:54
OA Status:Closed