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Spatial Genomics: Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows (Small 23/2021)


Voith von Voithenberg, Lena; Kashyap, Aditya; Opitz, Lennart; Aquino, Catharine; Sykes, Timothy; Nieser, Maike; Petrini, Lorenzo F T; Enrriquez Casimiro, Nadia; Kooten, Xander F; Biskup, Saskia; Schlapbach, Ralph; Schraml, Peter; Kaigala, Govind V (2021). Spatial Genomics: Mapping Spatial Genetic Landscapes in Tissue Sections through Microscale Integration of Sampling Methodology into Genomic Workflows (Small 23/2021). Small, 17(23):2170112.

Abstract

The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co-workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct corruptions at different spatial and temporal coordinates. Since these cells reside in several interacting ecosystems, it becomes very critical to study the spatial mutational landscape to evaluate and quantify tumor progression.

Abstract

The GeneScape workflow, presented in article number 2007901 by Govind V. Kaigala and co-workers, uses a modular multipurpose microfluidic probe to facilitate evaluation of spatial genomic heterogeneity in tumors. Cancer cells essentially contain the same genomic blueprint but accumulate distinct corruptions at different spatial and temporal coordinates. Since these cells reside in several interacting ecosystems, it becomes very critical to study the spatial mutational landscape to evaluate and quantify tumor progression.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Functional Genomics Center Zurich
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:Biomaterials, Biotechnology, General Materials Science, General Chemistry
Language:English
Date:1 June 2021
Deposited On:26 Jan 2022 06:06
Last Modified:26 Apr 2024 01:39
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1613-6810
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/smll.202170112
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