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Long-Term Immune-Related Adverse Events after Discontinuation of Immunotherapy


Horisberger, Karoline; Portenkirchner, Carmen; Rickenbacher, Andreas; Biedermann, Luc; Gubler, Christoph; Turina, Matthias (2021). Long-Term Immune-Related Adverse Events after Discontinuation of Immunotherapy. Immunotherapy, 13(9):735-740.

Abstract

Immune checkpoint inhibitors have revolutionized the treatment of various cancers but are notorious for their potential to cause severe side effects. While most side effects occur during ongoing therapy, an increasing number of reports of late onset have emerged. It is also not yet clear how long side effects can last. Resolution is achieved under symptomatic therapy, but the side effects may persist latently. We present a patient case with recurrence of colitis after closure of an ileostomy over 1 year after discontinuation of immune checkpoint inhibitor therapy with nivolumab and ipilimumab. To the best of our knowledge, no other case with severe colitis still lasting after more than a year of suspension of therapy has yet been reported.

Abstract

Immune checkpoint inhibitors have revolutionized the treatment of various cancers but are notorious for their potential to cause severe side effects. While most side effects occur during ongoing therapy, an increasing number of reports of late onset have emerged. It is also not yet clear how long side effects can last. Resolution is achieved under symptomatic therapy, but the side effects may persist latently. We present a patient case with recurrence of colitis after closure of an ileostomy over 1 year after discontinuation of immune checkpoint inhibitor therapy with nivolumab and ipilimumab. To the best of our knowledge, no other case with severe colitis still lasting after more than a year of suspension of therapy has yet been reported.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Health Sciences > Oncology
Uncontrolled Keywords:Oncology, Immunology, Immunology and Allergy
Language:English
Date:1 June 2021
Deposited On:01 Feb 2022 15:39
Last Modified:28 Dec 2023 02:42
Publisher:Future Medicine
ISSN:1750-743X
Additional Information:Case Report
OA Status:Closed
Publisher DOI:https://doi.org/10.2217/imt-2020-0320
Official URL:https://www.futuremedicine.com/doi/10.2217/imt-2020-0320
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