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Epigenetics of childhood trauma: Long term sequelae and potential for treatment


Thumfart, Kristina M; Jawaid, Ali; Bright, Kristina; Flachsmann, Marc; Mansuy, Isabelle M (2022). Epigenetics of childhood trauma: Long term sequelae and potential for treatment. Neuroscience and Biobehavioral Reviews, 132:1049-1066.

Abstract

Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk factors for neuropsychiatric diseases in adulthood. Recent advances in the field of epigenetics suggest that epigenetic factors such as DNA methylation and histone modifications, as well as regulatory processes involving non-coding RNA are associated with the long-term sequelae of CT. This narrative review summarizes current knowledge on the epigenetic basis of CT and describes studies in animal models and human subjects examining how the epigenome and transcriptome are modified by CT in the brain. It discusses psychological and pharmacological interventions that can counteract epigenetic changes induced by CT and the need to establish longitudinal assessment after CT for developing more effective diagnostics and treatment strategies based on epigenetic targets.

Abstract

Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk factors for neuropsychiatric diseases in adulthood. Recent advances in the field of epigenetics suggest that epigenetic factors such as DNA methylation and histone modifications, as well as regulatory processes involving non-coding RNA are associated with the long-term sequelae of CT. This narrative review summarizes current knowledge on the epigenetic basis of CT and describes studies in animal models and human subjects examining how the epigenome and transcriptome are modified by CT in the brain. It discusses psychological and pharmacological interventions that can counteract epigenetic changes induced by CT and the need to establish longitudinal assessment after CT for developing more effective diagnostics and treatment strategies based on epigenetic targets.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Social Sciences & Humanities > Neuropsychology and Physiological Psychology
Life Sciences > Cognitive Neuroscience
Life Sciences > Behavioral Neuroscience
Uncontrolled Keywords:Behavioral Neuroscience, Cognitive Neuroscience, Neuropsychology and Physiological Psychology
Language:English
Date:1 January 2022
Deposited On:03 Feb 2022 07:16
Last Modified:26 Apr 2024 01:40
Publisher:Elsevier
ISSN:0149-7634
OA Status:Hybrid
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.neubiorev.2021.10.042
PubMed ID:34742726
Project Information:
  • : FunderUniversität Zürich
  • : Grant ID
  • : Project Title
  • : FunderEidgenössische Technische Hochschule Zürich
  • : Grant ID
  • : Project Title
  • : FunderSNF
  • : Grant ID31003A_175742/1
  • : Project Title
  • : FunderH2020
  • : Grant ID848158
  • : Project TitleCausative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity
  • Content: Published Version
  • Language: English
  • Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)