Navigation auf zora.uzh.ch

Search ZORA

ZORA (Zurich Open Repository and Archive)

Treatment and follow-up of rare testis tumours

Fankhauser, Christian Daniel; Grogg, Josias Bastian; Rothermundt, Christian; Clarke, Noel William (2022). Treatment and follow-up of rare testis tumours. Journal of Cancer Research and Clinical Oncology, 148(3):667-671.

Abstract

PURPOSE

To provide recommendations for the follow-up of rare, clinically localised testis tumours, including Leydig, Sertoli or granulosa cell and spermatocytic tumours.

METHODS

Medline and Embase searches to identify published clinical trials, cohort studies, reviews, clinical practise guidelines and meta-analyses to design expert opinion-based follow-up schedules.

RESULTS

In four different systematic reviews, we previously identified 1375 men with Leydig, 435 with Sertoli, 239 with granulosa cell lesions and 146 with spermatocytic tumours. Local recurrence after testis-sparing surgery (TSS) was observed in 7%, < 1% and 5% of men with Leydig, Sertoli and granulosa cell tumours: no reports were available regarding recurrence after TSS in men with spermatocytic tumours. Distant recurrence was observed in 6%, 4%, 4% and 7% of the first four tumour types, respectively: metastasis was never reported in granulosa cell tumours of juvenile type. For patients with metastatic disease, complete response after surgical resection was reported in 10%, 18%, 43% and 4%. Complete response after chemotherapy was reported in 5%, 0%, 29% and 4%. There was no report of patients responding to radiotherapy alone.

CONCLUSIONS

We have collated the existing data about local and distant recurrence and response to treatment in men with rare testicular tumours and propose new recommendations for follow-up with cross-sectional imaging, stratified for each histological subtype.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:1 March 2022
Deposited On:09 Feb 2022 16:02
Last Modified:27 Oct 2024 02:37
Publisher:Springer
ISSN:0171-5216
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00432-021-03890-2
PubMed ID:35048196

Metadata Export

Statistics

Citations

Dimensions.ai Metrics
1 citation in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 09 Feb 2022
0 downloads since 12 months
Detailed statistics

Authors, Affiliations, Collaborations

Similar Publications