Header

UZH-Logo

Maintenance Infos

Convenient Cyclopentadiene Modifications for Building Versatile (Radio‐)Metal Cyclopentadienyl Frameworks


Lengacher, Raphael; Braband, Henrik; Csucker, Joshua; Alberto, Roger (2021). Convenient Cyclopentadiene Modifications for Building Versatile (Radio‐)Metal Cyclopentadienyl Frameworks. European Journal of Inorganic Chemistry, 2021(16):1611-1614.

Abstract

The synthesis of a bifunctional cyclopentadiene-based building block, bearing an alkyl linker with a terminal chloride and an ester group is described. This building block was modified by nucleophilic substitution, leading to two new fac-[Re(CO)3]+ containing derivatives of known drug candidates for brain imaging and multi-drug resistance in cancer in as few as two steps. Furthermore, the chloride was replaced by an azide, which was subsequently coupled to phenylacetylene as a model alkyne to demonstrate its versatility for undergoing Click-type reactions. The resulting triazole was labelled with 99mTc to yield the corresponding piano-stool complex in a radiochemical purity of 86 %. The identities were confirmed by coinjection with the Re homologue.

Abstract

The synthesis of a bifunctional cyclopentadiene-based building block, bearing an alkyl linker with a terminal chloride and an ester group is described. This building block was modified by nucleophilic substitution, leading to two new fac-[Re(CO)3]+ containing derivatives of known drug candidates for brain imaging and multi-drug resistance in cancer in as few as two steps. Furthermore, the chloride was replaced by an azide, which was subsequently coupled to phenylacetylene as a model alkyne to demonstrate its versatility for undergoing Click-type reactions. The resulting triazole was labelled with 99mTc to yield the corresponding piano-stool complex in a radiochemical purity of 86 %. The identities were confirmed by coinjection with the Re homologue.

Statistics

Citations

Dimensions.ai Metrics
4 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

35 downloads since deposited on 14 Feb 2022
16 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Physical Sciences > Inorganic Chemistry
Uncontrolled Keywords:Inorganic Chemistry
Language:English
Date:26 April 2021
Deposited On:14 Feb 2022 15:57
Last Modified:28 Mar 2024 02:34
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1434-1948
OA Status:Green
Publisher DOI:https://doi.org/10.1002/ejic.202100163
  • Content: Accepted Version