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The “Carbonyl Story” and Beyond; Experiences, Lessons and Implications


Alberto, Roger (2020). The “Carbonyl Story” and Beyond; Experiences, Lessons and Implications. Chembiochem, 21(19):2743-2749.

Abstract

The complex [99m Tc(OH2 )3 (CO)3 ]+ has become a versatile building block in radiopharmaceutical chemistry, applied by many groups worldwide. However, despite widespread efforts, only one compound has made it right the way through clinical trials. Along the way from its discovery to its development into an eventual product, the author experienced issues that he would handle differently in retrospect. In this article, these experiences are turned into "lessons" that might be helpful for young researchers finding themselves in similar situations. Beside issues with patenting and company strategies, the carbonyl story has provided scientific implications beyond its own story, and insights from which any future 99m Tc-based chemistry for radiopharmacy or molecular imaging might benefit.

Abstract

The complex [99m Tc(OH2 )3 (CO)3 ]+ has become a versatile building block in radiopharmaceutical chemistry, applied by many groups worldwide. However, despite widespread efforts, only one compound has made it right the way through clinical trials. Along the way from its discovery to its development into an eventual product, the author experienced issues that he would handle differently in retrospect. In this article, these experiences are turned into "lessons" that might be helpful for young researchers finding themselves in similar situations. Beside issues with patenting and company strategies, the carbonyl story has provided scientific implications beyond its own story, and insights from which any future 99m Tc-based chemistry for radiopharmacy or molecular imaging might benefit.

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15 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Life Sciences > Biochemistry
Life Sciences > Molecular Medicine
Life Sciences > Molecular Biology
Physical Sciences > Organic Chemistry
Uncontrolled Keywords:Organic Chemistry, Molecular Biology, Molecular Medicine, Biochemistry
Language:English
Date:1 October 2020
Deposited On:14 Feb 2022 16:17
Last Modified:28 Mar 2024 02:34
Publisher:Wiley-VCH Verlag
ISSN:1439-4227
OA Status:Green
Publisher DOI:https://doi.org/10.1002/cbic.202000387
  • Content: Accepted Version