Collective variables (CVs) are crucial parameters in enhanced sampling calculations and strongly impact the quality of the obtained free energy surface. However, many existing CVs are unique to and dependent on the system they are constructed with, making the developed CV non-transferable to other systems. Herein, we develop a non-instructor-led deep autoencoder neural network (DAENN) for discovering general-purpose CVs. The DAENN is used to train a model by learning molecular representations upon unbiased trajectories that contain only the reactant conformers. The prior knowledge of nonconstraint reactants coupled with the here-introduced topology variable and loss-like penalty function are only required to make the biasing method able to expand its configurational (phase) space to unexplored energy basins. Our developed autoencoder is efficient and relatively inexpensive to use in terms of a priori knowledge, enabling one to automatically search for hidden CVs of the reaction of interest.