In this paper, we propose simple exact procedures for testing both a location shift and/or a scale change between two multivariate distributions. Our tests are strictly distribution-free and can be made either scale invariant or rotation invariant. Our approach combines a generalization of the Wilcoxon test based on projections of the data onto the first principal component, a generalization of the Siegel–Tukey test based on the concept of data depth, and a bivariate test for the location problem proposed by K. V. Mardia (1967, J. Roy. Statist. Soc. Ser. B29, 320–342). In addition, we show that the limiting null distribution of a test statistic proposed by R. Y. Liu and K. Singh (1993, J. Amer. Statist. Assoc.88, 252–260) does not depend on the depth considered.