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Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter

Riemenschnitter, Cosima E; Morand, Grégoire B; Schouten, Charlotte S; Rupp, Niels J; Balermpas, Panagiotis; Gander, Thomas; Broglie Däppen, Martina A (2023). Need for adjuvant radiotherapy in oral cancer: depth of invasion rather than tumor diameter. European Archives of Oto-Rhino-Laryngology, 280(1):339-346.

Abstract

PURPOSE

The 8th edition of the TNM Cancer Staging Manual incorporates depth of invasion (DOI) into the pathologic tumor classification for oral squamous cell carcinoma (OSSC). While deep invading tumors with small tumor diameters (TD) have been categorized as early stage tumors in the 7th edition, they are now upstaged, potentially influencing the decision to initiate adjuvant radiotherapy (RT).

METHODS

OSCC patients surgically treated with curative intent between 2010 and 2019 were consecutively included. Tumors were staged based on TD only (according to the 7th edition TNM Cancer Staging Manual), then restaged based solely on DOI.

RESULTS

Of the 133 included patients, 58 patients (43.6%) had a different pT-stage when using DOI instead of TD for staging (upstaging in 23.3%). Overall survival (OS) was significantly worse in patients who were upstaged with DOI. In addition, stratification by adjuvant RT showed significant worse OS in upstaged patients without receiving adjuvant RT.

CONCLUSIONS

DOI seems to be an import indicator for adjuvant RT in OSCC-patients.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > Center for Dental Medicine > Clinic of Cranio-Maxillofacial Surgery
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Otorhinolaryngology
Language:English
Date:1 January 2023
Deposited On:03 Oct 2022 14:54
Last Modified:28 Oct 2024 02:36
Publisher:Springer
ISSN:0937-4477
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/s00405-022-07561-x
PubMed ID:35913631
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