Header

UZH-Logo

Maintenance Infos

A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate


Caiado, Francisco; Manz, Markus G (2022). A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate. Cell Stem Cell, 29(2):177-179.

Abstract

The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.

Abstract

The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.

Statistics

Citations

Dimensions.ai Metrics

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology and Hematology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Molecular Medicine
Life Sciences > Genetics
Life Sciences > Cell Biology
Language:English
Date:3 February 2022
Deposited On:31 Oct 2022 07:44
Last Modified:26 Dec 2023 08:00
Publisher:Cell Press (Elsevier)
ISSN:1875-9777
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.stem.2022.01.009
PubMed ID:35120614
Full text not available from this repository.