Caiado, Francisco; Manz, Markus G (2022). A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate. Cell Stem Cell, 29(2):177-179.
The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.
The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology and Hematology |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Molecular Medicine
Life Sciences > Genetics Life Sciences > Cell Biology |
| Language: | English |
| Date: | 3 February 2022 |
| Deposited On: | 31 Oct 2022 07:44 |
| Last Modified: | 01 Nov 2022 21:00 |
| Publisher: | Cell Press (Elsevier) |
| ISSN: | 1875-9777 |
| OA Status: | Closed |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | https://doi.org/10.1016/j.stem.2022.01.009 |
| PubMed ID: | 35120614 |
Caiado, Francisco