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Development of the circadian system in early life: maternal and environmental factors

Wong, Sachi D; Wright, Kenneth P; Spencer, Robert L; Vetter, Céline; Hicks, Laurel M; Jenni, Oskar G; LeBourgeois, Monique K (2022). Development of the circadian system in early life: maternal and environmental factors. Journal of Physiological Anthropology, 41:22.

Abstract

In humans, an adaptable internal biological system generates circadian rhythms that maintain synchronicity of behavior and physiology with the changing demands of the 24-h environment. Development of the circadian system begins in utero and continues throughout the first few years of life. Maturation of the clock can be measured through sleep/wake patterns and hormone secretion. Circadian rhythms, by definition, can persist in the absence of environmental input; however, their ability to adjust to external time cues is vital for adaptation and entrainment to the environment. The significance of these external factors that influence the emergence of a stable circadian clock in the first years of life remain poorly understood. Infants raised in our post-modern world face adverse external circadian signals, such as artificial light and mistimed hormonal cues via breast milk, which may increase interference with the physiological mechanisms that promote circadian synchronization. This review describes the very early developmental stages of the clock and common circadian misalignment scenarios that make the developing circadian system more susceptible to conflicting time cues and temporal disorder between the maternal, fetal, infant, and peripheral clocks.

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Social Sciences & Humanities > Human Factors and Ergonomics
Life Sciences > Physiology
Health Sciences > Orthopedics and Sports Medicine
Social Sciences & Humanities > Anthropology
Health Sciences > Public Health, Environmental and Occupational Health
Health Sciences > Physiology (medical)
Uncontrolled Keywords:Physiology (medical), Public Health, Environmental and Occupational Health, Anthropology, Orthopedics and Sports Medicine, Physiology, Human Factors and Ergonomics
Language:English
Date:16 May 2022
Deposited On:02 Nov 2022 13:14
Last Modified:28 Oct 2024 02:37
Publisher:Nihon Seiri Jinrui Gakkai
ISSN:1880-6791
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/s40101-022-00294-0
PubMed ID:35578354
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