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The interplay of genetic and environmental factors in shaping well-being across the lifespan: Evidence from the serotonin transporter gene


Gärtner, Matti; Grimm, Simone; Aust, Sabine; Fan, Yan; von Scheve, Christian; Bajbouj, Malek (2018). The interplay of genetic and environmental factors in shaping well-being across the lifespan: Evidence from the serotonin transporter gene. Aging & Mental Health, 22(9):1216-1222.

Abstract

BACKGROUND

Converging evidence suggests that well-being plays an important role in promoting and maintaining mental health across the life span. It has been shown that well-being has a considerable heritable component, but little is known about the specific genes involved.

METHODS

In this study, we investigated a healthy sample (N = 298) that was genotyped for the serotonin transporter-linked polymorphic region (5-HTTLPR). We hypothesized that 5-HTTLPR gene variation would influence well-being, and additionally investigated interaction effects with age and the environmental influence of early life stress (ELS).

RESULTS

Using multiple regression, our results showed a significant three-way interaction between genotype, ELS, and age. Exploration of this interaction showed that young subjects had decreased levels of well-being if they were exposed to ELS and homozygous for the short variant of 5-HTTLPR. This relationship was reversed in old age: subjects that were exposed to ELS and carried the long variant of 5-HTTLPR had decreased levels of well-being.

CONCLUSION

Our results indicate that genetic and environmental factors have joint effects on well-being that are susceptible to profound changes across the life span.

Abstract

BACKGROUND

Converging evidence suggests that well-being plays an important role in promoting and maintaining mental health across the life span. It has been shown that well-being has a considerable heritable component, but little is known about the specific genes involved.

METHODS

In this study, we investigated a healthy sample (N = 298) that was genotyped for the serotonin transporter-linked polymorphic region (5-HTTLPR). We hypothesized that 5-HTTLPR gene variation would influence well-being, and additionally investigated interaction effects with age and the environmental influence of early life stress (ELS).

RESULTS

Using multiple regression, our results showed a significant three-way interaction between genotype, ELS, and age. Exploration of this interaction showed that young subjects had decreased levels of well-being if they were exposed to ELS and homozygous for the short variant of 5-HTTLPR. This relationship was reversed in old age: subjects that were exposed to ELS and carried the long variant of 5-HTTLPR had decreased levels of well-being.

CONCLUSION

Our results indicate that genetic and environmental factors have joint effects on well-being that are susceptible to profound changes across the life span.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Psychiatric Mental Health
Health Sciences > Gerontology
Health Sciences > Geriatrics and Gerontology
Health Sciences > Psychiatry and Mental Health
Language:English
Date:September 2018
Deposited On:07 Nov 2022 12:25
Last Modified:27 Apr 2024 01:41
Publisher:Taylor & Francis
ISSN:1360-7863
OA Status:Closed
Publisher DOI:https://doi.org/10.1080/13607863.2017.1348467
PubMed ID:28685605
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